Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues,Nature Materials

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Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues
Nature Materials ( IF 37.2 ) Pub Date : 2021-07-29 , DOI: 10.1038/s41563-021-01051-x
Quansan Yang _{1,

2,

3} , Tong Wei ₄ , Rose T Yin ₅ , Mingzheng Wu ₆ , Yameng Xu _{7,

8} , Jahyun Koo ₉ , Yeon Sik Choi _{1,

2,

7} , Zhaoqian Xie _{10,

11,

12} , Sheena W Chen ₁₃ , Irawati Kandela _{14,

15} , Shenglian Yao ₁₆ , Yujun Deng _{3,

17} , Raudel Avila ₃ , Tzu-Li Liu ₃ , Wubin Bai _{1,

2,

7,

18} , Yiyuan Yang _{1,

2,

3} , Mengdi Han _{1,

2} , Qihui Zhang ₇ , Chad R Haney _{15,

19,

20} , K Benjamin Lee ₁₃ , Kedar Aras ₅ , Tong Wang ₄ , Min-Ho Seo _{1,

2,

7,

21} , Haiwen Luan _{1,

2,

3} , Seung Min Lee ₇ , Anlil Brikha _{15,

19} , Nayereh Ghoreishi-Haack ₁₄ , Lori Tran _{14,

15} , Iwona Stepien _{14,

15} , Fraser Aird ₁₅ , Emily A Waters _{15,

19,

20} , Xinge Yu ₂₂ , Anthony Banks _{1,

2} , Gregory D Trachiotis _{5,

23} , John M Torkelson _{4,

7} , Yonggang Huang _{1,

3,

7,

24} , Yevgenia Kozorovitskiy _{6,

15} , Igor R Efimov ₅ , John A Rogers _{1,

2,

3,

7,

20,

25}

Affiliation

Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL, USA.
Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA.
Department of Mechanical Engineering, Northwestern University, Evanston, IL, USA.
Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.
Department of Biomedical Engineering, The George Washington University, Washington, DC, USA.
Department of Neurobiology, Northwestern University, Evanston, IL, USA.
Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.
The Institute of Materials Science and Engineering, Washington University in St. Louis, St. Louis, MO, USA.
School of Biomedical Engineering, Korea University, Seoul, Republic of Korea.
State Key Laboratory of Structural Analysis for Industrial Equipment, Dalian University of Technology, Dalian, China.
Department of Engineering Mechanics, Dalian University of Technology, Dalian, China.
Ningbo Institute of Dalian University of Technology, Ningbo, China.
Department of Surgery, The George Washington University, Washington, DC, USA.
Developmental Therapeutics Core, Northwestern University, Evanston, IL, USA.
Chemistry Life Processes Institute, Northwestern University, Evanston, IL, USA.
School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, China.
State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong University, Shanghai, China.
Department of Applied Physical Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Center for Advanced Molecular Imaging, Northwestern University, Evanston, IL, USA.
Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
School of Biomedical Convergence Engineering, College of Information & Biomedical Engineering, Pusan National University, Pusan, Republic of Korea.
Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China.
DC Veterans Affairs Medical Center, The George Washington University, Washington, DC, USA.
Departments of Civil and Environmental Engineering, Northwestern University, Evanston, IL, USA.
Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Flexible electronic/optoelectronic systems that can intimately integrate onto the surfaces of vital organ systems have the potential to offer revolutionary diagnostic and therapeutic capabilities relevant to a wide spectrum of diseases and disorders. The critical interfaces between such technologies and living tissues must provide soft mechanical coupling and efficient optical/electrical/chemical exchange. Here, we introduce a functional adhesive bioelectronic–tissue interface material, in the forms of mechanically compliant, electrically conductive, and optically transparent encapsulating coatings, interfacial layers or supporting matrices. These materials strongly bond both to the surfaces of the devices and to those of different internal organs, with stable adhesion for several days to months, in chemistries that can be tailored to bioresorb at controlled rates. Experimental demonstrations in live animal models include device applications that range from battery-free optoelectronic systems for deep-brain optogenetics and subdermal phototherapy to wireless millimetre-scale pacemakers and flexible multielectrode epicardial arrays. These advances have immediate applicability across nearly all types of bioelectronic/optoelectronic system currently used in animal model studies, and they also have the potential for future treatment of life-threatening diseases and disorders in humans.

中文翻译：

光固化生物可吸收粘合剂作为柔性生物电子设备和软生物组织之间的功能界面

可以紧密集成到重要器官系统表面的柔性电子/光电系统有可能提供与广泛的疾病和病症相关的革命性诊断和治疗能力。这些技术与活组织之间的关键接口必须提供软机械耦合和高效的光/电/化学交换。在这里，我们介绍了一种功能性粘合剂生物电子组织界面材料，其形式为机械兼容、导电和光学透明的封装涂层、界面层或支撑矩阵。这些材料与设备表面和不同内部器官的表面都牢固结合，具有几天到几个月的稳定附着力，在可以以受控速率进行生物再吸收的化学物质中。活体动物模型的实验演示包括从用于深部脑光遗传学和皮下光疗的无电池光电系统到无线毫米级起搏器和灵活的多电极心外膜阵列的设备应用。这些进展立即适用于目前用于动物模型研究的几乎所有类型的生物电子/光电系统，它们也有可能在未来治疗人类危及生命的疾病和病症。活体动物模型的实验演示包括从用于深部脑光遗传学和皮下光疗的无电池光电系统到无线毫米级起搏器和灵活的多电极心外膜阵列的设备应用。这些进展立即适用于目前用于动物模型研究的几乎所有类型的生物电子/光电系统，它们也有可能在未来治疗人类危及生命的疾病和病症。活体动物模型的实验演示包括从用于深部脑光遗传学和皮下光疗的无电池光电系统到无线毫米级起搏器和灵活的多电极心外膜阵列的设备应用。这些进展立即适用于目前用于动物模型研究的几乎所有类型的生物电子/光电系统，它们也有可能在未来治疗人类危及生命的疾病和病症。

更新日期：2021-07-29

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