NASH is an advanced stage of liver disease accompanied by lipid accumulation, inflammation, and liver fibrosis. Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2) is a member of the “inhibitory” class of α-subunits, and recent studies showed that Gnai2 deficiency is known to cause reduced weight in mice. However, the role of GNAI2 in hepatocytes, particularly in the context of liver inflammation and lipid metabolism, remains to be elucidated. Herein, we aim to ascertain the function of GNAI2 in hepatocytes and its impact on the development of NASH.

中文翻译：

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鸟嘌呤核苷酸结合蛋白 G(i) 亚基 Alpha 2 通过调节过氧还蛋白 1 相关的炎症和脂肪吞噬来加剧 NASH 进展

NASH 是肝脏疾病的晚期阶段，伴有脂质积累、炎症和肝纤维化。鸟嘌呤核苷酸结合蛋白 G(i) 亚基 alpha-2 (GNAI2) 是“抑制”类 α-亚基的成员，最近的研究表明，已知Gnai2缺乏会导致小鼠体重减轻。然而，GNAI2 在肝细胞中的作用，特别是在肝脏炎症和脂质代谢的情况下，仍有待阐明。在此，我们旨在确定 GNAI2 在肝细胞中的功能及其对 NASH 发展的影响。