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LSD1-Demethylated LINC01134 Confers Oxaliplatin Resistance Through SP1-Induced p62 Transcription in HCC
Hepatology ( IF 12.9 ) Pub Date : 2021-07-29 , DOI: 10.1002/hep.32079 Luyuan Ma 1, 2 , An Xu 3 , Lei Kang 4 , Rui Cong 2 , Zhongyi Fan 5 , Xiang Zhu 2 , Nan Huo 2 , Wenpeng Liu 1 , Chunyuan Xue 2 , Quanbo Ji 6 , Wenchao Li 7 , Zhong Chu 2 , Xiaofeng Kang 2 , Yadong Wang 1 , Zhijia Sun 2 , Yuchen Han 2 , Hanxiao Liu 2 , Xiang Gao 8 , Juqiang Han 7 , Hua You 9 , Caiyan Zhao 1 , Xiaojie Xu 2
Hepatology ( IF 12.9 ) Pub Date : 2021-07-29 , DOI: 10.1002/hep.32079 Luyuan Ma 1, 2 , An Xu 3 , Lei Kang 4 , Rui Cong 2 , Zhongyi Fan 5 , Xiang Zhu 2 , Nan Huo 2 , Wenpeng Liu 1 , Chunyuan Xue 2 , Quanbo Ji 6 , Wenchao Li 7 , Zhong Chu 2 , Xiaofeng Kang 2 , Yadong Wang 1 , Zhijia Sun 2 , Yuchen Han 2 , Hanxiao Liu 2 , Xiang Gao 8 , Juqiang Han 7 , Hua You 9 , Caiyan Zhao 1 , Xiaojie Xu 2
Affiliation
Oxaliplatin (OXA) is one of the most common chemotherapeutics in advanced hepatocellular carcinoma (HCC), the resistance of which poses a big challenge. Long noncoding RNAs (lncRNAs) play vital roles in chemoresistance. Therefore, elucidating the underlying mechanisms and identifying predictive lncRNAs for OXA resistance is needed urgently.
中文翻译：
LSD1 去甲基化 LINC01134 通过 SP1 诱导的 p62 转录在 HCC 中赋予奥沙利铂耐药性
奥沙利铂（OXA）是晚期肝细胞癌（HCC）最常见的化疗药物之一，其耐药性带来了巨大的挑战。长链非编码 RNA (lncRNA) 在化疗耐药中发挥着重要作用。因此，迫切需要阐明 OXA 耐药的潜在机制并鉴定预测性 lncRNA。
更新日期：2021-07-29
中文翻译：
LSD1 去甲基化 LINC01134 通过 SP1 诱导的 p62 转录在 HCC 中赋予奥沙利铂耐药性
奥沙利铂（OXA）是晚期肝细胞癌（HCC）最常见的化疗药物之一，其耐药性带来了巨大的挑战。长链非编码 RNA (lncRNA) 在化疗耐药中发挥着重要作用。因此，迫切需要阐明 OXA 耐药的潜在机制并鉴定预测性 lncRNA。
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