ABSTRACT

This study enumerates the quantitative measurement of optical parameters used in several diagnostic procedures for malignant tissue. Optical diagnosis is proposed due to its non-invasive and non-destructive nature. This paper recapitulates Fresnel equation (polarization independent) to determine the characteristic critical angle of malignant tissue. The critical angle of malignant tissue is lower than healthier tissue and is therefore an optical parameter of interest for lesion tissue diagnosis. Similarly, a quantitative analysis is derived to commensurate refractive index and absorption and reflective property of tissue and its nuance with healthier counterparts. The second dichotomy of the research concentrates on comparing and validating the mathematical analysis with COMSOL Multiphysics® 5.2 simulation. The magnitude of malignant tissue reflectance is obtained across a range of incident angle ranging from 0° to 90°. The simulation results satiate the quantitative analysis with only 1.3% deviation. This quantitative result provides prospect of collaborating bio-electromagnetism results with Artificial Intelligence technology for active disease progression diagnosis utilizing minimum invasive diagnostic procedure.

摘要

本研究列举了用于恶性组织的几种诊断程序的光学参数的定量测量。光学诊断因其非侵入性和非破坏性而被提出。本文概括了菲涅耳方程（与极化无关）以确定恶性组织的特征临界角。恶性组织的临界角低于健康组织，因此是病变组织诊断的重要光学参数。类似地，通过定量分析得出组织的折射率、吸收和反射特性及其与健康对应物的细微差别。研究的第二个二分法侧重于比较和验证数学分析与 COMSOL Multiphysics® 5.2 仿真。在从 0° 到 90° 的入射角范围内获得恶性组织反射率的大小。模拟结果满足定量分析，只有 1.3% 的偏差。这一定量结果为生物电磁学结果与人工智能技术的合作提供了利用最小侵入性诊断程序进行主动疾病进展诊断的前景。