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Gastro-esophageal pharmacobezoar
Forensic Science, Medicine and Pathology ( IF 1.8 ) Pub Date : 2021-07-29 , DOI: 10.1007/s12024-021-00404-x
Roger W. Byard 1 , Marc Grabowski 2
Affiliation  

A 35-year-old man with schizophrenia died from an overdose of propranolol (blood level = 60 mg/L). Post mortem CT scanning showed marked distension of the esophagus by granular material with a bolus of similar material within the stomach. At autopsy 62 g of lime green pharmacobezoar was present within the esophagus with an additional 130gm mass of similar material within the stomach, both of which contained propranolol. The rest of the gastrointestinal tract was unremarkable. The mouth, pharynx, glottis, larynx, trachea and bronchi were all structurally normal with no obstructive material. Thus, there was no evidence of airway compromise to suggest that the bezoar had mechanically contributed to death. Rather, elution of the drug had resulted in lethal blood levels. The color of the pharmacobezoar derived from the green color of certain propranolol tablets. Death was therefore attributed to propranolol toxicity with an associated finding of a massive gastro-esophageal pharmacobezoar.



中文翻译:

胃食管药黄

一名患有精神分裂症的 35 岁男性死于过量服用普萘洛尔(血药浓度 = 60 mg/L)。死后 CT 扫描显示,胃内有颗粒状物质和类似物质的团块,使食道明显膨胀。尸检时,食道内存在 62 克柠檬绿药石黄,胃内存在 130 克类似物质,两者均含有普萘洛尔。其余胃肠道无异常。口、咽、声门、喉、气管、支气管结构正常,无阻塞物。因此,没有气道受损的证据表明牛黄在机械上导致了死亡。相反,药物的洗脱导致了致命的血液浓度。药石黄的颜色源自某些普萘洛尔片剂的绿色。因此,死亡归因于普萘洛尔毒性以及大量胃食管药黄石的相关发现。

更新日期:2021-07-29
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