The loss of stability of the blood liquid state causes changes in the blood aggregation, resulting in thrombus formation. Intravascular thrombus formation is intensely studied within modern biophysics by the methods of mathematical simulation. Determining the conditions of shear-induced platelet activation has opened an opportunity for the estimation of thrombus formation risks in particular clinical settings. In this paper, a new approach is proposed to determine the risks of shear-induced thrombus formation. This approach is applicable for a wide range of objects including aorta and mechanical circulatory assist devices. The geometry of the vascular walls in numerical experiments is chosen to be isomorphic to that of the blood vessels in a human body. Promising ways to reduce the risks of thrombus formation activation in high blood flows have been found. The developed technique can be used by physicians to plan personalized strategies for antithrombotic therapy based on individual shear-induced platelet activation risks.

血液液体状态失去稳定性，引起血液聚集的变化，导致血栓形成。现代生物物理学通过数学模拟方法对血管内血栓形成进行了深入研究。确定剪切诱导的血小板活化条件为评估特定临床环境中的血栓形成风险提供了机会。在本文中，提出了一种新方法来确定剪切诱导血栓形成的风险。这种方法适用于广泛的对象，包括主动脉和机械循环辅助装置。数值实验中血管壁的几何形状被选择为与人体血管的几何形状同构。已经找到了降低高血流中血栓形成激活风险的有希望的方法。医生可以使用开发的技术根据个体剪切诱导的血小板活化风险来规划抗血栓治疗的个性化策略。