SARS-CoV-2 infection can affect all human beings, including pregnant women. Thus, understanding the immunological changes induced by the virus during pregnancy is nowadays of pivotal importance. Here, using peripheral blood from 14 pregnant women with asymptomatic or mild SARS-CoV-2 infection, we investigate cell proliferation and cytokine production, measure plasma levels of 62 cytokines, and perform a 38-parameter mass cytometry analysis. Our results show an increase in low density neutrophils but no lymphopenia or gross alterations of white blood cells, which display normal levels of differentiation, activation or exhaustion markers and show well preserved functionality. Meanwhile, the plasma levels of anti-inflammatory cytokines such as interleukin (IL)-1RA, IL-10 and IL-19 are increased, those of IL-17, PD-L1 and D-dimer are decreased, but IL-6 and other inflammatory molecules remain unchanged. Our profiling of antiviral immune responses may thus help develop therapeutic strategies to avoid virus-induced damages during pregnancy.

SARS-CoV-2 感染可影响所有人，包括孕妇。因此，了解病毒在怀孕期间引起的免疫学变化在当今至关重要。在这里，我们使用来自 14 名无症状或轻度 SARS-CoV-2 感染的孕妇的外周血，研究细胞增殖和细胞因子的产生，测量 62 种细胞因子的血浆水平，并进行 38 参数质谱分析。我们的结果显示低密度中性粒细胞增加，但没有淋巴细胞减少或白细胞的总体改变，显示出正常水平的分化、激活或耗竭标志物，并显示出保存完好的功能。同时，血浆中白细胞介素（IL）-1RA、IL-10和IL-19等抗炎细胞因子水平升高，IL-17、PD-L1和D-二聚体水平降低，但 IL-6 和其他炎症分子保持不变。因此，我们对抗病毒免疫反应的分析可能有助于制定治疗策略，以避免怀孕期间病毒引起的损害。