Given the fast-growing demand for anti-trafficking measures, this article investigates the development of voltammetric sensors for the oxidation of cocaine hydrochloride on the surface of carbon paste electrodes chemically modified with Schiff base complexes and their potential use for cocaine detection and quantification in seized samples. Voltammetric analyses revealed that [Co^II(salen)] displayed amperometric and thermal stability, was uniformly distributed on the electrode surface, was only degraded at temperatures above 300 °C, and did not undergo passivation in acid medium. The [Co^II(salen)]-modified voltammetric sensor gave error below 10%, an improvement on HPLC. SIMCA chemometric analyses predicted the group belonging to cocaine hydrochloride and its interferents effectively, attesting to the good selectivity and specificity of the developed sensor. The sensor has potential application in forensic investigations: its LOD and LOQ, intra and inter-day precision, accuracy, linearity ranges, selectivity, specificity, and sensitivity are better as compared to other chemically modified electrodes. Finally, the Density Functional Theory (DFT) method confirmed the oxidation–reduction mechanisms proposed in the literature.

鉴于对反贩运措施的需求快速增长，本文研究了伏安法传感器的开发，用于在用希夫碱配合物化学修饰的碳糊电极表面氧化盐酸可卡因，及其在缉获的可卡因检测和定量中的潜在用途。样品。伏安分析表明，[Co ^II (salen)] 显示出电流和热稳定性，均匀分布在电极表面，仅在高于 300 °C 的温度下降解，并且在酸性介质中不会发生钝化。[Co ^II(salen)]-改进的伏安传感器误差低于 10%，这是对 HPLC 的改进。SIMCA 化学计量学分析有效地预测了属于盐酸可卡因的组及其干扰物，证明了所开发传感器的良好选择性和特异性。该传感器在法医调查中具有潜在应用：与其他化学修饰电极相比，其 LOD 和 LOQ、日内和日间精度、准确度、线性范围、选择性、特异性和灵敏度更好。最后，密度泛函理论（DFT）方法证实了文献中提出的氧化还原机制。