15-Deoxy-Δ-^12,14-prostaglandin J2 (15d-PGJ2) is an endogenous agonist of the ligand dependent transcriptional factor, peroxisome proliferator-activated receptor –gamma (PPAR-γ). Although PPAR-γ mediates some actions of 15d-PGJ2, many actions of 15d-PGJ2 are independent of PPAR-γ. The PPAR-γ signaling pathway has beneficial effects on tumor progression, inflammation, oxidative stress, and angiogenesis in numerous studies. In this review, various studies were analyzed to understand the effects of 15d-PGJ2 in vascular smooth muscle cells (VSMC)s. 15d-PGJ2 inhibits proliferation of VSMCs during vascular remodeling and it alters the expression of contractile proteins and inflammatory components within these cells as well. However, the effects of 15d-PGJ2 as well as its ability to induce PPAR-γ activation remains controversial as contradictory effects of this prostaglandin in VSMCs exist. Understanding the mechanisms by which 15d-PGJ2 elicit beneficial actions whether by PPAR-γ activation or independently, will aid in developing new therapeutic strategies for diseases such as hypertension with an inflammatory component. Although great advances are being made, more research is needed to reach definitive conclusions.

15-Deoxy-Δ- ^12,14 -prostaglandin J2 (15d-PGJ2) 是配体依赖性转录因子过氧化物酶体增殖物激活受体 -gamma (PPAR- γ ) 的内源性激动剂。尽管 PPAR- γ介导 15d-PGJ2 的某些作用，但 15d-PGJ2 的许多作用独立于 PPAR- γ 。许多研究表明，PPAR- γ信号通路对肿瘤进展、炎症、氧化应激和血管生成具有有益影响。在本综述中，分析了各种研究以了解 15d-PGJ2 对血管平滑肌细胞 (VSMC) 的影响。 15d-PGJ2 在血管重塑过程中抑制 VSMC 的增殖，并改变这些细胞内收缩蛋白和炎症成分的表达。然而，15d-PGJ2 的作用及其诱导 PPAR- γ激活的能力仍然存在争议，因为这种前列腺素在 VSMC 中存在矛盾的作用。了解 15d-PGJ2 通过 PPAR- γ激活或独立引起有益作用的机制，将有助于开发针对具有炎症成分的高血压等疾病的新治疗策略。尽管正在取得巨大进展，但仍需要更多研究才能得出明确的结论。