The NS1 protein of flaviviruses is taking center stage. Recent work has made it an attractive target for development of vaccines and immunotherapeutics. Cavazzoni and colleagues (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210580) now reveal a dark side to NS1, linking it to the development of self-reactive antibodies.

中文翻译：

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NS1 抗体的阴暗面？


黄病毒的 NS1 蛋白正在成为焦点。最近的工作使其成为疫苗和免疫治疗药物开发的有吸引力的目标。 Cavazzoni 及其同事 (2021. J. Exp. Med. https://doi.org/10.1084/jem.20210580) 现在揭示了 NS1 的阴暗面，将其与自身反应性抗体的发展联系起来。