Clinical and preclinical studies have reported that Lactobacillus gasseri BNR17, a probiotic bacterial strain isolated from human breast milk, reduces body weight and white adipose tissue volume. In order to further explore the actions of L. gasseri BNR17, we investigated the anti-menopausal effects of L. gasseri BNR17 in an ovariectomized (OVX) rat model. The serum alanine aminotransferase levels of the rats in the OVX-BNR17 group were lower than those of the rats in the OVX-vehicle only (OVX-Veh) group. Upon administration of L. gasseri BNR17 after ovariectomy, calcitonin and Serotonin 2A levels increased significantly, whereas serum osteocalcin levels showed a decreasing tendency. Compared to the rats in the OVX-Veh group, those in the OVX-BNR17 group showed lower urine deoxypyridinoline levels, lower pain sensitivity, and improved vaginal cornification. Furthermore, L. gasseri BNR17 administration increased bone mineral density in the rats with OVX-induced femoral bone loss. These results suggest that L. gasseri BNR17 administration could alleviate menopausal symptoms, indicating that this bacterium could be a good functional probiotic for managing the health of older women.

中文翻译：

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格氏乳杆菌 BNR17 对去卵巢大鼠绝经后症状的影响。

临床和临床前研究报告称，格氏乳杆菌BNR17 是一种从人类母乳中分离出来的益生菌菌株，可减轻体重和白色脂肪组织体积。为了进一步探索L. gasseri BNR17 的作用，我们研究了L. gasseri BNR17 在卵巢切除 (OVX) 大鼠模型中的抗绝经作用。OVX-BNR17 组大鼠的血清谷丙转氨酶水平低于仅 OVX 载体 (OVX-Veh) 组大鼠。给予L. gasseri卵巢切除后BNR17，降钙素和5-羟色胺2A水平显着升高，而血清骨钙素水平呈下降趋势。与 OVX-Veh 组的大鼠相比，OVX-BNR17 组的大鼠表现出较低的尿液脱氧吡啶啉水平、较低的疼痛敏感性和改善的阴道角质化。此外，L. gasseri BNR17 给药增加了 OVX 诱导的股骨骨丢失大鼠的骨矿物质密度。这些结果表明，L. gasseri BNR17 给药可以缓解更年期症状，表明这种细菌可能是管理老年妇女健康的良好功能性益生菌。