Osteoarthritis (OA) is characterized by persistent destruction of articular cartilage. It has been found that microRNAs (miRNAs) are closely related to the occurrence and development of OA. The purpose of the present study was to investigate the mechanism of miR-486 in the development and progression of OA.

中文翻译：

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MicroRNA-486 通过靶向 SIRT6 促进软骨细胞样细胞的更多分解代谢表型：可能参与骨关节炎中的软骨降解。


骨关节炎（OA）的特点是关节软骨持续破坏。研究发现微小RNA（miRNA）与OA的发生、发展密切相关。本研究的目的是探讨miR-486在OA发生和进展中的作用机制。