Facioscapulohumeral Muscular Dystrophy (FSHD) is in the top three list of all dystrophies with an approximate 1:8000 incidence. It is not a life-threatening disease; however, the progression of the disease extends over being wheelchair bound. Despite some drug trials continuing, including DUX4 inhibition, TGF-ß inhibition and resokine which promote healthier muscle, there is not an applicable treatment option for FSHD today. Still, there is a need for new agents to heal, stop or at least slow down muscle wasting. Current FSHD studies involving nutraceuticals as vitamin C, vitamin E, coenzyme Q10, zinc, selenium, and phytochemicals as curcumin or genistein, daidzein flavonoids provide promising treatment strategies. In this review, we present the clinical and molecular nature of FSHD and focus on nutraceuticals and phytochemicals that may alleviate FSHD. In the light of the association of impaired pathophysiological FSHD pathways with nutraceuticals and phytochemicals according to the literature, we present both studied and novel approaches that can contribute to FSHD treatment.

面肩肱型肌营养不良症 (FSHD) 是所有营养不良症中排名前三的，发病率约为 1:8000。它不是危及生命的疾病；然而，疾病的进展超出了坐轮椅的范围。尽管一些药物试验仍在继续，包括促进肌肉健康的 DUX4 抑制、TGF-β 抑制和利索红 (resokine)，但目前还没有适用于 FSHD 的治疗选择。尽管如此，仍然需要新的药物来治愈、阻止或至少减缓肌肉萎缩。目前的 FSHD 研究涉及维生素 C、维生素 E、辅酶 Q10、锌、硒等营养保健品以及姜黄素或染料木黄酮、大豆黄酮等植物化学物质，提供了有前景的治疗策略。在这篇综述中，我们介绍了 FSHD 的临床和分子性质，并重点关注可以缓解 FSHD 的营养保健品和植物化学物质。根据文献，FSHD 病理生理学途径受损与营养保健品和植物化学物质之间的关联，我们提出了有助于 FSHD 治疗的研究方法和新颖方法。