To analyze the risk factors of invasive pulmonary fungal infections in patients with HBV-ACL, the clinical data and risk factors of 60 patients with HBV-ACLF complicated IPFI were analyzed retrospectively including clinical parameters, broad-spectrum antibiotics usage, neutropenia, invasive medical manipulations, serum total bilirubin, international normalized ratio (INR), and MELD scores were compared with non-IPFI. Risk factors were analyzed using mathematical tools. Candida species and Aspergillus were detected as the most prominent fungal strains (61.11% and 33.33%, respectively). The risk factors included prolong broad-spectrum antibiotic usage , neutropenia , invasive procedures , serum total bilirubin , INR , and MELD scores . Candida is the main IPFI strains in patients with HBV-ACLF. Broad-spectrum antibiotics usage, neutropenia, invasive manipulations, and the severity of ACLF might be risk factors for IPFI in patients with HBV-ACLF.

中文翻译：

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乙型肝炎病毒相关急慢性肝衰竭患者侵袭性肺部真菌感染的危险因素

为分析HBV-ACL患者侵袭性肺部真菌感染的危险因素，回顾性分析60例HBV-ACLF并发IPFI患者的临床资料和危险因素，包括临床参数、广谱抗生素使用、中性粒细胞减少、侵入性医疗操作将血清总胆红素、国际标准化比值 (INR) 和 MELD 评分与非 IPFI 进行比较。使用数学工具分析风险因素。念珠菌属和曲霉属被检测为最突出的真菌菌株（分别为 61.11% 和 33.33%）。风险因素包括延长广谱抗生素的使用,中性粒细胞减少症,侵入性程序,血清总胆红素,印度卢比,和 MELD 分数. 念珠菌是 HBV-ACLF 患者的主要 IPFI 菌株。广谱抗生素的使用、中性粒细胞减少、侵入性操作和 ACLF 的严重程度可能是 HBV-ACLF 患者 IPFI 的危险因素。