The (pro)renin receptor is a multifunctional protein with roles in angiotensin-II-dependent and -independent intracellular cell signaling and roles as an intracellular accessory protein for the vacuolar H⁺-ATPase, including hormone secretion. While (pro)renin receptor mRNA is widely expressed in various human tissues, localization of (pro)renin receptor protein expression has not yet been systemically determined. Therefore, this study localized (pro)renin receptor protein expression in human organs. Systemic immunohistochemical examination of (pro)renin receptor expression was performed in whole body organs of autopsy cases. (Pro)renin receptor immunostaining was observed in the cytoplasm of cells in almost all human organs. It was observed in thyroid follicular epithelial cells, hepatic cells, pancreatic duct epithelial cells, zona glomerulosa and zona reticularis of the cortex and medulla of the adrenal gland, proximal and distal tubules and collecting ducts of the kidney, cardiomyocytes, and skeletal muscle cells. In the brain, (pro)renin receptor staining was detected in neurons throughout all areas, especially in the medulla oblongata, paraventricular nucleus and supraoptic nucleus of the hypothalamus, cerebrum, granular layer of the hippocampus, Purkinje cell layer of the cerebellum, and the pituitary anterior and posterior lobes. In the anterior lobe of the pituitary gland, all types of anterior pituitary hormone-positive cells showed double staining with (pro)renin receptor. These data showed that (pro)renin receptor protein was expressed in almost all organs of the human body. Its expression pattern was not uniform, and cell-specific expression pattern was observed, supporting the notion that (pro)renin receptor plays numerous physiological roles in each human organ.

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人类（原）肾素受体的免疫组织化学

（原）肾素受体是一种多功能蛋白，在血管紧张素 II 依赖性和非依赖性细胞内信号传导中起作用，并作为液泡 H ⁺的细胞内辅助蛋白-ATPase，包括激素分泌。虽然（原）肾素受体 mRNA 在各种人体组织中广泛表达，但尚未系统地确定（原）肾素受体蛋白表达的定位。因此，本研究定位了（原）肾素受体蛋白在人体器官中的表达。在尸检病例的全身器官中进行（原）肾素受体表达的全身免疫组织化学检查。在几乎所有人体器官的细胞质中都观察到（原）肾素受体免疫染色。在甲状腺滤泡上皮细胞、肝细胞、胰管上皮细胞、肾上腺皮质和髓质的肾小球带和网状带、肾近端和远端小管和集合管、心肌细胞和骨骼肌细胞中观察到。在大脑中，（原）肾素受体染色在所有区域的神经元中均被检测到，特别是在延髓、室旁核和下丘脑的视上核、大脑、海马颗粒层、小脑浦肯野细胞层和垂体前部和后部裂片。在垂体前叶，所有类型的垂体前叶激素阳性细胞都显示出与（原）肾素受体的双重染色。这些数据表明（原）肾素受体蛋白在人体几乎所有器官中均有表达。它的表达模式不统一，并且观察到细胞特异性表达模式，支持（原）肾素受体在每个人体器官中发挥多种生理作用的观点。下丘脑的室旁核和视上核、大脑、海马颗粒层、小脑浦肯野细胞层、垂体前叶和后叶。在垂体前叶，所有类型的垂体前叶激素阳性细胞都显示出与（原）肾素受体的双重染色。这些数据表明（原）肾素受体蛋白在人体几乎所有器官中均有表达。它的表达模式不统一，并且观察到细胞特异性表达模式，支持（原）肾素受体在每个人体器官中发挥多种生理作用的观点。下丘脑的室旁核和视上核、大脑、海马颗粒层、小脑浦肯野细胞层、垂体前叶和后叶。在垂体前叶，所有类型的垂体前叶激素阳性细胞都显示出与（原）肾素受体的双重染色。这些数据表明（原）肾素受体蛋白在人体几乎所有器官中均有表达。它的表达模式不统一，并且观察到细胞特异性表达模式，支持（原）肾素受体在每个人体器官中发挥多种生理作用的观点。在垂体前叶，所有类型的垂体前叶激素阳性细胞都显示出与（原）肾素受体的双重染色。这些数据表明（原）肾素受体蛋白在人体几乎所有器官中均有表达。它的表达模式不统一，并且观察到细胞特异性表达模式，支持（原）肾素受体在每个人体器官中发挥多种生理作用的观点。在垂体前叶，所有类型的垂体前叶激素阳性细胞都显示出与（原）肾素受体的双重染色。这些数据表明（原）肾素受体蛋白在人体几乎所有器官中均有表达。它的表达模式不统一，并且观察到细胞特异性表达模式，支持（原）肾素受体在每个人体器官中发挥多种生理作用的观点。