The Chenopodium genus is a plant family widely spread worldwide that includes various plant species reputed to possess several medicinal virtues in folk medicines. Chenopodium ambrosioides L. is among the most used plants in traditional medicines worldwide. This review aimed to highlight ethnomedicinal uses, phytochemical status, and pharmacological properties of C. ambrosioides L. The analysis of relevant data highlights various ethnomedicinal uses against human and veterinary diseases in forty countries. Most indications consisted of gastrointestinal tract dysfunctioning troubles and worms parasitemia. Around 330 chemical compounds have been identified in different plant parts, especially in its essential oil fractions (59.84%). However, only a few compounds—mainly monoterpenes and glycosides—have been isolated and characterized. Experimental pharmacological studies validated a large scale of significant health benefits. It appeared that many monoterpenes are antioxidant, insecticidal, trypanocidal, analgesic, antifungal, anti-inflammatory, anti-arthritic, acaricidal, amoebicidal, anthelmintic, anticancer, antibacterial, antidiabetic, antidiarrheal, antifertility, antifungal, anti-leishmanial, antimalarial, antipyretic, antisickling, antischistosomal, antiulcer, anxiolytic, immunomodulatory, molluscicidal, and vasorelaxant agents. Thus, the Chenopodium ambrosioides species necessitates further chemical studies to isolate and characterize new bioactive secondary metabolites and pharmacological investigations to precise the mechanisms of action before clinical trials.

中文翻译：

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Chenopodium ambrosioides L. 的民族医学用途、化学成分和循证药理特性：广泛概述

藜属是一种在世界范围内广泛传播的植物科，其中包括在民间医学中被认为具有多种药用功效的多种植物。Chenopodium ambrosioides L. 是全球传统药物中使用最广泛的植物之一。本综述旨在突出 C. ambrosioides L 的民族医学用途、植物化学状态和药理特性。相关数据的分析突出了四十个国家中针对人类和兽医疾病的各种民族医学用途。大多数适应症包括胃肠道功能障碍和蠕虫寄生虫血症。在植物的不同部位，尤其是其精油馏分中，已鉴定出大约 330 种化合物（59.84%）。然而，只有少数化合物——主要是单萜和糖苷——被分离和表征。实验药理学研究证实了大规模的显着健康益处。许多单萜似乎具有抗氧化、杀虫、杀锥虫、镇痛、抗真菌、抗炎、抗关节炎、杀螨、杀阿米巴、驱虫、抗癌、抗菌、抗糖尿病、止泻、抗生育、抗真菌、抗利什曼原虫、抗疟疾、解热、抗镰刀、抗血吸虫、抗溃疡、抗焦虑、免疫调节、杀软体动物和血管舒张剂。因此，Chenopodium ambrosioides 物种需要进一步的化学研究以分离和表征新的生物活性次级代谢物和药理学研究，以在临床试验前精确确定作用机制。许多单萜似乎具有抗氧化、杀虫、杀锥虫、镇痛、抗真菌、抗炎、抗关节炎、杀螨、杀阿米巴、驱虫、抗癌、抗菌、抗糖尿病、止泻、抗生育、抗真菌、抗利什曼原虫、抗疟疾、解热、抗镰刀、抗血吸虫、抗溃疡、抗焦虑、免疫调节、杀软体动物和血管舒张剂。因此，Chenopodium ambrosioides 物种需要进一步的化学研究以分离和表征新的生物活性次级代谢物和药理学研究，以在临床试验前精确确定作用机制。许多单萜似乎具有抗氧化、杀虫、杀锥虫、镇痛、抗真菌、抗炎、抗关节炎、杀螨、杀阿米巴、驱虫、抗癌、抗菌、抗糖尿病、止泻、抗生育、抗真菌、抗利什曼原虫、抗疟疾、解热、抗镰刀、抗血吸虫、抗溃疡、抗焦虑、免疫调节、杀软体动物和血管舒张剂。因此，Chenopodium ambrosioides 物种需要进一步的化学研究以分离和表征新的生物活性次级代谢物和药理学研究，以在临床试验前精确确定作用机制。抗生育、抗真菌、抗利什曼原虫、抗疟疾、解热、抗镰刀、抗血吸虫、抗溃疡、抗焦虑、免疫调节、杀软体动物和血管舒张剂。因此，Chenopodium ambrosioides 物种需要进一步的化学研究以分离和表征新的生物活性次级代谢物和药理学研究，以在临床试验前精确确定作用机制。抗生育、抗真菌、抗利什曼原虫、抗疟疾、解热、抗镰刀、抗血吸虫、抗溃疡、抗焦虑、免疫调节、杀软体动物和血管舒张剂。因此，Chenopodium ambrosioides 物种需要进一步的化学研究以分离和表征新的生物活性次级代谢物和药理学研究，以在临床试验前精确确定作用机制。