Background Hypertrophic scars are one of the main complications that affect the quality of life of patients after burns. Many methods have been shown to be effective in the treatment of hypertrophic scars, such as ablative fractional CO2 laser (AFCL) and platelet-rich plasma (PRP). However, there are few studies on the effect of the combined application of these measures. The purpose of this study was to explore the therapeutic effect of AFCL combined with PRP on hypertrophic burn scars. Methods A retrospective clinical observation study was conducted on 50 patients with hypertrophic burn scars. The AFCL+PRP group included 31 patients who received AFCL combined with PRP treatment; the AFCL group included 19 patients who received AFCL treatment only. The University of North Carolina 4P Scar Scale (UNC4P) and the Vancouver Scar Scale (VSS) scores that were collected before each treatment were used as indicators of the effectiveness of the previous treatment. The scores recorded at the second, fourth and seventh months were analysed. Results The demographic data of the 2 groups were not significantly different. Before treatment, there was no difference in the UNC4P and VSS scores between the 2 groups. There was a significant decline in the UNC4P and VSS total scores over 6 months in both groups (p < 0.05) and scores in the 2 groups were comparable after 3 and 6 months (p < 0.05). UNC4P scores in the AFCL+PRP group decreased from a mean of 8.26 to 2.61 (p < 0.05) with a concomitant drop in VSS scores from a mean of 11.74 to 6.06 (p < 0.01). In the AFCL group UNC4P and VSS scores decreased from 7.68 to 4.63 (p < 0.05) and from 10.89 to 8.16 (p < 0.05), respectively. The sub-items of these 2 assessments were analysed and the results suggest that AFCL combined with PRP can comprehensively improve scarring. Conclusions This study shows that PRP is an effective adjunct for AFCL in the treatment of hypertrophic burn scars and that the combination of PRP and AFCL proved to be more useful than AFCL alone. This combination may be a new and effective clinical practice for the treatment of scars. However, larger and higher-level clinical studies are still needed to determine its efficacy and possible mechanisms.

中文翻译：

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消融点阵二氧化碳激光联合富血小板血浆治疗改善肥厚性瘢痕：一项回顾性临床观察研究

背景 肥厚性瘢痕是影响烧伤患者生活质量的主要并发症之一。许多方法已被证明可有效治疗肥厚性瘢痕，例如消融分数 CO2 激光 (AFCL) 和富血小板血浆 (PRP)。然而，关于这些措施联合应用的效果的研究很少。本研究旨在探讨AFCL联合PRP治疗肥厚性烧伤瘢痕的疗效。方法对50例肥厚性烧伤瘢痕患者进行回顾性临床观察研究。AFCL+PRP组包括31例接受AFCL联合PRP治疗的患者；AFCL 组包括 19 名仅接受 AFCL 治疗的患者。每次治疗前收集的北卡罗来纳大学 4P 疤痕量表 (UNC4P) 和温哥华疤痕量表 (VSS) 评分用作先前治疗效果的指标。分析了在第二个月、第四个月和第七个月记录的分数。结果 2组人口统计学资料无显着差异。治疗前，2组UNC4P和VSS评分无差异。两组的 UNC4P 和 VSS 总分在 6 个月内都有显着下降（p < 0.05），并且两组在 3 个月和 6 个月后的得分相当（p < 0.05）。AFCL+PRP 组的 UNC4P 评分从平均值 8.26 下降到 2.61 (p < 0.05)，同时 VSS 评分从平均值 11.74 下降到 6.06 (p < 0.01)。在 AFCL 组中，UNC4P 和 VSS 分数分别从 7.68 下降到 4.63 (p < 0.05) 和从 10.89 下降到 8.16 (p < 0.05)。对这2项评估的子项进行分析，结果表明AFCL联合PRP可以全面改善瘢痕形成。结论 本研究表明，PRP 是 AFCL 治疗肥厚性烧伤瘢痕的有效辅助手段，并且 PRP 和 AFCL 的组合被证明比单独的 AFCL 更有用。这种组合可能是治疗疤痕的一种新的有效的临床实践。然而，仍需要更大规模和更高水平的临床研究来确定其疗效和可能的机制。对这2项评估的子项进行分析，结果表明AFCL联合PRP可以全面改善瘢痕形成。结论 本研究表明，PRP 是 AFCL 治疗肥厚性烧伤瘢痕的有效辅助手段，并且 PRP 和 AFCL 的组合被证明比单独的 AFCL 更有用。这种组合可能是治疗疤痕的一种新的有效的临床实践。然而，仍需要更大规模和更高水平的临床研究来确定其疗效和可能的机制。对这2项评估的子项进行分析，结果表明AFCL联合PRP可以全面改善瘢痕形成。结论 本研究表明，PRP 是 AFCL 治疗肥厚性烧伤瘢痕的有效辅助手段，并且 PRP 和 AFCL 的组合被证明比单独的 AFCL 更有用。这种组合可能是治疗疤痕的一种新的有效的临床实践。然而，仍需要更大规模和更高水平的临床研究来确定其疗效和可能的机制。这种组合可能是治疗疤痕的一种新的有效的临床实践。然而，仍需要更大规模和更高水平的临床研究来确定其疗效和可能的机制。这种组合可能是治疗疤痕的一种新的有效的临床实践。然而，仍需要更大规模和更高水平的临床研究来确定其疗效和可能的机制。