Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease that affects the large intestine and exhibits a relapsing and remitting course. It is a complex immune-mediated disease of the gastrointestinal tract that increases morbidity and negatively influences the quality of life. Although our previous studies have indicated that CD30L is involved in the adaptive immune response in UC, it remains unclear whether it participates in the innate immune response. Our results revealed that the CD30L level significantly increased in the circulating classical monocytes of patients with UC and showed a positive correlation with the severity of UC. CD30L may participate in monocyte-mediated inflammation in patients with UC through the activation of circulating classical monocytes. The present study provides insights into a marker of severity and a potential target for the development of immunological therapy of UC.

溃疡性结肠炎 (UC) 是一种影响大肠的慢性特发性炎症性肠病，具有复发和缓解过程。它是一种复杂的免疫介导的胃肠道疾病，会增加发病率并对生活质量产生负面影响。虽然我们之前的研究表明 CD30L 参与了 UC 的适应性免疫反应，但它是否参与先天免疫反应仍不清楚。我们的结果显示，UC 患者循环经典单核细胞中 CD30L 水平显着增加，并与 UC 的严重程度呈正相关。CD30L 可能通过激活循环经典单核细胞参与 UC 患者的单核细胞介导的炎症。