Adhesive hydrogels have attracted wide attention as wound dressings. However, conventional wound dressings that passively promote healing usually show limited efficacy. Although various drugs or cells are introduced to drive the healing process, such strategies are limited by the complicated fabrication process. Here, a mechanically active adhesive and immune regulative dressing is developed, mainly consisting of temperature-sensitive hydrogel with semi-interpenetrating network structure. This hydrogel could strongly adhere to and actively contract the wound in a ready-to-use form, where the freeze-dried hydrogel and sterile saline are sealed in two separated packages. More interestingly, the interspersed poly(methacrylic acid) could further promote wound healing via increasing the formation of new blood vessels and modulating inflammatory responses. In vivo mouse and porcine wound models validate the accelerated wound healing enabled by active contraction and modulated inflammatory responses. This mechanobiological and immune regulative dressing may provide a new avenue for wound management.

粘性水凝胶作为伤口敷料引起了广泛关注。然而，被动促进愈合的传统伤口敷料通常表现出有限的功效。尽管引入了各种药物或细胞来驱动愈合过程，但这些策略受到复杂的制造过程的限制。在这里，开发了一种机械活性粘合剂和免疫调节敷料，主要由具有半互穿网络结构的温度敏感水凝胶组成。这种水凝胶可以立即使用的形式强烈粘附并主动收缩伤口，其中冷冻干燥的水凝胶和无菌盐水密封在两个单独的包装中。更有趣的是，体内小鼠和猪伤口模型验证了由主动收缩和调节炎症反应实现的加速伤口愈合。这种机械生物学和免疫调节敷料可能为伤口管理提供新的途径。