Introduction: Alzheimer’s disease (AD), which is characterized by abnormal deposition of amyloid-β (Aβ) plaques and impaired neurogenesis and cognition, still lacks an optimally effective therapeutic agent for its management, and mounting evidence has shown that inflammatory processes are implicated in AD. Sophocarpine has been reported to exert inflammation-regulating effects in various diseases. However, whether sophocarpine can exert anti-neuroinflammatory and neuroprotective effects in AD remains unclear. This study investigated whether sophocarpine could ameliorate the pathological features and potential mechanisms in a mouse AD model. Methods: APP/PS1 mice were treated with sophocarpine for 8 weeks. We quantified the effects of sophocarpine treatment on cognitive performance using a behavioral test. Brain Aβ deposits and neurogenesis were evaluated using immunofluorescence staining. We also assessed the morphology and inflammatory changes induced by sophocarpine administration and its expression in the hippocampus. Results: Administration of sophocarpine significantly alleviated cognitive impairment and reduced neural loss. APP/PS1 mice treated with sophocarpine showed reduced Aβ plaque deposits and enhanced neurogenesis. Sophocarpine markedly decreased the expression of inflammation markers and inhibited microglial activation. Conclusions: Sophocarpine could potentially alleviate cognitive impairment and brain damage in APP/PS1 mice with its neuroprotective effects via modulation of the inflammatory pathway.
Neuroimmunomodulation

中文翻译：

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槐果碱减轻认知障碍并促进阿尔茨海默病小鼠模型的神经发生

简介：阿尔茨海默病 (AD) 的特征是淀粉样蛋白 β (Aβ) 斑块的异常沉积以及神经发生和认知受损，仍然缺乏最佳有效的治疗药物，并且越来越多的证据表明炎症过程与广告。据报道槐果碱在各种疾病中发挥炎症调节作用。然而，槐果碱是否能在 AD 中发挥抗神经炎症和神经保护作用尚不清楚。本研究调查槐果碱是否可以改善小鼠 AD 模型的病理特征和潜在机制。方法：APP/PS1 小鼠用槐果碱治疗 8 周。我们使用行为测试量化了槐果碱治疗对认知能力的影响。使用免疫荧光染色评估脑 Aβ 沉积和神经发生。我们还评估了槐果碱给药诱导的形态和炎症变化及其在海马中的表达。结果：槐果碱的给药显着减轻了认知障碍并减少了神经损失。用槐果碱治疗的 APP/PS1 小鼠表现出 Aβ 斑块沉积减少和神经发生增强。槐果碱显着降低炎症标志物的表达并抑制小胶质细胞的激活。结论：槐果碱可通过调节炎症通路发挥神经保护作用，从而潜在地减轻 APP/PS1 小鼠的认知障碍和脑损伤。
神经免疫调节