Photochemical Synthesis of Nonplanar Small Molecules with Ultrafast Nonradiative Decay for Highly Efficient Phototheranostics,Advanced Materials

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Photochemical Synthesis of Nonplanar Small Molecules with Ultrafast Nonradiative Decay for Highly Efficient Phototheranostics
Advanced Materials ( IF 27.4 ) Pub Date : 2021-07-28 , DOI: 10.1002/adma.202102799
Xiaozhen Li _{1,

2} , Di Zhang _{3,

4} , Guihong Lu ₅ , Tingchao He ₆ , Yingpeng Wan _{1,

2} , Man-Kit Tse ₃ , Can Ren ₆ , Pengfei Wang _{2,

7} , Shengliang Li _{1,

8} , Jingdong Luo _{3,

4} , Chun-Sing Lee _{1,

2}

Affiliation

There has been much recent progress in the development of photothermal agents (PTAs) for biomedical and energy applications. Synthesis of organic PTAs typically involves noble metal catalysts and high temperatures. On the other hand, photochemical synthesis, as an alternative and green chemical technology, has obvious merits such as low cost, energy efficiency, and high yields. However, photochemical reactions have rarely been employed for the synthesis of PTAs. Herein, a facile and high-yield photochemical reaction is exploited for synthesizing nonplanar small molecules (NSMs) containing strong Michler's base donors and a tricyanoquinodimethane acceptor as high-performance PTAs. The synthesized NSMs show interesting photophysical properties including good absorption for photons of over 1000 nm wavelength, high near-infrared extinction coefficients, and excellent photothermal performance. Upon assembling the NSMs into nanoparticles (NSMN), they exhibit good biocompatibility, high photostability, and excellent photothermal conversion efficiency of 75%. Excited-state dynamic studies reveal that the NSMN has ultrafast nonradiative decay after photoexcitation. With these unique properties, the NSMN achieves efficient in vivo photoacoustic imaging and photothermal tumor ablation. This work demonstrates the superior potential of photochemical reactions for the synthesis of high-performance molecular PTAs.

中文翻译：

超快非辐射衰变非平面小分子的光化学合成用于高效光治疗

用于生物医学和能源应用的光热剂（PTA）的开发最近取得了很多进展。有机 PTA 的合成通常涉及贵金属催化剂和高温。另一方面，光化学合成作为一种替代性的绿色化学技术，具有成本低、能源效率高、产率高等明显优点。然而，光化学反应很少用于PTA的合成。在此，利用简便且高产率的光化学反应来合成含有强米氏碱基供体和三氰基醌二甲烷受体的非平面小分子（NSM）作为高性能 PTA。合成的 NSM 显示出有趣的光物理特性，包括对 1000 nm 波长以上光子的良好吸收、高近红外消光系数和优异的光热性能。将 NSM 组装成纳米颗粒 (NSMN) 后，它们表现出良好的生物相容性、高光稳定性和高达 75% 的优异光热转换效率。激发态动态研究表明，NSMN 在光激发后具有超快的非辐射衰变。凭借这些独特的特性，NSMN 实现了高效的体内光声成像和光热肿瘤消融。这项工作展示了光化学反应在合成高性能分子 PTA 方面的卓越潜力。

更新日期：2021-09-21

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