Decreased levels of immune-regulatory cytokines in patients with immune thrombocytopenia and long-lasting overexpression of these cytokines in the splenectomized patients,Journal of Leukocyte Biology

当前位置： X-MOL 学术 › J. Leukoc. Biol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Decreased levels of immune-regulatory cytokines in patients with immune thrombocytopenia and long-lasting overexpression of these cytokines in the splenectomized patients
Journal of Leukocyte Biology ( IF 3.6 ) Pub Date : 2021-07-28 , DOI: 10.1002/jlb.5ab0521-621rr
Xiaofeng Wang _{1,

2} , Feng Li _{1,

2} , Yang Li ₁ , Lihua Sun ₁ , Yahong Meng ₁ , Xiaohong Fan ₁ , Xuelian Wang ₁ , Duojiao Wu _{3,

4} , Yunfeng Cheng _{1,

2,

3,

4} , Fanli Hua ₁

Affiliation

Immune thrombocytopenia (ITP) is an autoimmune-mediated disease characterized by decreased platelet counts. Cytokines play important roles in modulating the immune response and are involved in the pathogenesis of many autoimmune diseases. This study aimed at exploring the serum levels of a core set of cytokines that exert immune-regulatory functions in newly diagnosed ITP patients (both before and after treatment) and splenectomized ITP patients. Using the Bio-Plex suspension array system and ELISA, the serum levels of IL-10, IL-21, IL-27, IL-33, IL-35, IL-37, and TGF-β₁ were detected. The data showed that the serum levels of the immune regulatory cytokines IL-10, IL-35, and TGF-β₁ were significantly lower in newly diagnosed ITP patients. Decreased cytokine levels could be improved in patients with a complete response or a response after steroid-based treatment(s). The serum concentrations of TGF-β₁ were positively correlated with the platelet counts both before and after treatment. All the detected immune-regulatory cytokines, except IL-37, showed significantly higher levels in splenectomized ITP patients than pretreatment ITP patients and healthy controls. In conclusion, these data suggest that lower levels of immune-regulatory cytokines are involved in the pathogenesis of ITP and that there is a long-lasting overexpression of immune-regulatory cytokines in ITP patients with splenectomy.

中文翻译：

免疫性血小板减少症患者免疫调节细胞因子水平降低，脾切除患者长期过度表达这些细胞因子

免疫性血小板减少症 (ITP) 是一种自身免疫介导的疾病，其特征是血小板计数减少。细胞因子在调节免疫反应中起重要作用，并参与许多自身免疫疾病的发病机制。本研究旨在探索在新诊断的 ITP 患者（治疗前后）和脾切除的 ITP 患者中发挥免疫调节功能的一组核心细胞因子的血清水平。使用Bio-Plex的悬浮阵列系统和ELISA，IL-10的血清水平，IL-21，IL-27，IL-33，IL-35，IL-37和TGF-β ₁进行检测。数据表明，免疫调节性细胞因子IL-10，IL-35和TGF-β的血清水平₁在新诊断的 ITP 患者中显着降低。在基于类固醇的治疗后完全缓解或缓解的患者中，降低的细胞因子水平可以得到改善。TGF-β的血清浓度₁与前和处理后的血小板计数呈正相关。除 IL-37 外，所有检测到的免疫调节细胞因子在脾切除的 ITP 患者中均显示出显着高于治疗前 ITP 患者和健康对照的水平。总之，这些数据表明较低水平的免疫调节细胞因子参与了 ITP 的发病机制，并且在 ITP 脾切除术患者中存在免疫调节细胞因子的长期过度表达。

更新日期：2021-07-28

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11