NDR/LATS-family protein kinase genes are indispensable for embryogenesis in Arabidopsis,FEBS Open Bio

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NDR/LATS-family protein kinase genes are indispensable for embryogenesis in Arabidopsis
FEBS Open Bio ( IF 2.8 ) Pub Date : 2021-07-28 , DOI: 10.1002/2211-5463.13257
Hyuk Sung Yoon ₁ , Kaien Fujino ₂ , Shenkui Liu ₃ , Tetsuo Takano ₁ , Daisuke Tsugama ₁

Affiliation

NDR/LATS-family protein kinases are conserved among eukaryotes. These protein kinases in yeast and animals phosphorylate specific targets and regulate the cell cycle. Arabidopsis thaliana has eight NDR/LATS-family protein kinase genes (NDR1-8), of which NDR2, NDR4, and NDR5 are involved in regulating pollen development. However, the functions of the other NDR/LATS-family protein kinase genes in plants are unclear. Here, we show that three putative phosphorylation sites of an Arabidopsis basic leucine zipper transcription factor, VIP1, correspond to NDR/LATS-family protein kinase phosphorylation motifs and that two of these three sites are phosphorylated by NDR2, NDR3, or NDR8 in vitro. Expression of NDR1-8 was detected in various tissues. An NDR4 NDR6 NDR7 NDR8 quadruple mutation caused embryonic lethality These results suggest that different NDR/LATS-family protein kinases in plants have distinct physiological roles.

中文翻译：

NDR/LATS家族蛋白激酶基因对于拟南芥胚胎发生是必不可少的

NDR/LATS 家族蛋白激酶在真核生物中是保守的。酵母和动物中的这些蛋白激酶磷酸化特定靶标并调节细胞周期。拟南芥具有 8 个 NDR/LATS 家族蛋白激酶基因 ( NDR1-8 )，其中NDR2、NDR4和NDR5参与调控花粉发育。然而，植物中其他 NDR/LATS 家族蛋白激酶基因的功能尚不清楚。在这里，我们显示拟南芥碱性亮氨酸拉链转录因子 VIP1 的三个假定磷酸化位点对应于 NDR/LATS 家族蛋白激酶磷酸化基序，并且这三个位点中的两个在体外被 NDR2、NDR3 或 NDR8 磷酸化. 在各种组织中检测到NDR1-8的表达。NDR4 NDR6 NDR7 NDR8四重突变导致胚胎致死这些结果表明植物中不同的NDR/LATS家族蛋白激酶具有不同的生理作用。

更新日期：2021-09-01

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