Abstract

The incidence of liver cirrhosis is increasing worldwide. Patients with cirrhosis are generally at a higher risk of harbouring hepatic and non-hepatic malignancies, including bladder cancer, likely due to the presence of related risk factors such as smoking. Cirrhosis can complicate both the operative and non-surgical management of bladder cancer. For example, cirrhotic patients undergoing abdominal surgery generally demonstrate worse postoperative outcomes, and chemotherapy in patients with cirrhosis often requires dose reduction due to its direct hepatotoxic effects and reduced hepatic clearance. Multiple other considerations in the peri-operative management for cirrhosis patients with muscle-invasive bladder cancer must be taken into account to optimize outcomes in these patients. Unfortunately, the current literature specifically related to the treatment of cirrhotic bladder cancer patients remains sparse. We aim to review the literature on treatment considerations for this patient population with respect to perioperative, surgical, and adjuvant management.

中文翻译：

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肝硬化患者的肌肉浸润性膀胱癌——相关考虑因素的回顾

 抽象的

世界范围内肝硬化的发病率正在增加。肝硬化患者通常罹患肝脏和非肝脏恶性肿瘤（包括膀胱癌）的风险较高，这可能是由于存在吸烟等相关危险因素。肝硬化会使膀胱癌的手术和非手术治疗变得复杂。例如，接受腹部手术的肝硬化患者通常表现出较差的术后结果，而肝硬化患者的化疗由于其直接的肝毒性作用和肝脏清除率降低而通常需要减少剂量。在患有肌层浸润性膀胱癌的肝硬化患者的围手术期管理中，必须考虑多种其他因素，以优化这些患者的预后。不幸的是，目前专门与肝硬化膀胱癌患者治疗相关的文献仍然很少。我们的目的是回顾有关该患者群体在围手术期、手术和辅助管理方面的治疗注意事项的文献。