Flavan-3-ol Microbial Metabolites Modulate Proteolysis in Neuronal Cells Reducing Amyloid-beta (1-42) Levels,Molecular Nutrition & Food Research

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Flavan-3-ol Microbial Metabolites Modulate Proteolysis in Neuronal Cells Reducing Amyloid-beta (1-42) Levels
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2021-07-28 , DOI: 10.1002/mnfr.202100380
Valentina Cecarini ₁ , Massimiliano Cuccioloni ₁ , Yadong Zheng ₁ , Laura Bonfili ₁ , Chunmei Gong ₁ , Mauro Angeletti ₁ , Pedro Mena _{2,

3} , Daniele Del Rio _{2,

3} , Anna Maria Eleuteri ₁

Affiliation

Alzheimer's disease (AD) is a progressive neurodegeneration characterized by extensive protein aggregation and deposition in the brain, associated with defective proteasomal and autophagic-lysosomal proteolytic pathways. Since current drugs can only reduce specific symptoms, the identification of novel treatments is a major concern in AD research. Among natural compounds, (poly)phenols and their derivatives/metabolites are emerging as candidates in AD prevention due to their multiple beneficial effects. This study aims to investigate the ability of a selection of phenyl-γ-valerolactones, gut microbiota-derived metabolites of flavan-3-ols, to modulate the functionality of cellular proteolytic pathways.

中文翻译：

Flavan-3-ol 微生物代谢物调节神经元细胞中的蛋白水解，降低淀粉样蛋白 - β (1-42) 水平

阿尔茨海默病 (AD) 是一种进行性神经退行性疾病，其特征是大脑中广泛的蛋白质聚集和沉积，与蛋白酶体和自噬溶酶体蛋白水解途径缺陷相关。由于目前的药物只能减轻特定症状，因此寻找新的治疗方法是 AD 研究的主要关注点。在天然化合物中，（多）酚及其衍生物/代谢物由于其多种有益作用而成为 AD 预防的候选者。本研究旨在研究精选的苯基-γ-戊内酯（肠道微生物群衍生的黄烷-3-醇代谢物）调节细胞蛋白水解途径功能的能力。

更新日期：2021-09-22

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