Ruminants are not considered to experience nausea because they do not possess the emetic reflex. This study examined the effects of administration of cisplatin (cis-diamminedichloro platinum (II): CDDP), a common emetic agent, on the behavior of goats. In Experiment 1, adult Shiba goats received intravenous (IV) administration of CDDP. CDDP-administered goats spent a shorter time feeding (P < 0.01), lied down earlier (P < 0.01), and spent a longer period lying down (P < 0.01) than the saline-administered control goats, and sometimes, they directed their face downward and close their eyes. These behavioral responses were followed by a significant (P < 0.01) increase in plasma cortisol (Cor) levels, which indicated that goats experienced stress. The dose dependency was found in the extent of the CDDP effects. In Experiment 2, the effects of pretreatment of ondansetron (Ond), an antiemetic agent, were examined. Pretreatment of Ond extended the latency of lying (P < 0.01), shortened the time spent lying (P < 0.05), and reduced the extent of the increase in plasma Cor levels (P < 0.01). These results suggested that CDDP administration generated some state of stress in goats via the similar physiological mechanisms as emesis-caused stress in emetic species.

中文翻译：

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催吐剂顺铂对山羊行为和血浆皮质醇水平的影响

反刍动物不被认为会感到恶心，因为它们不具备呕吐反射。本研究检查了顺铂（顺铂（顺式-二氨二氯铂 (II)：CDDP）（一种常见的催吐剂）对山羊行为的影响。在实验 1 中，成年 Shiba 山羊接受了 CDDP 的静脉内 (IV) 给药。与生理盐水对照山羊相比，CDDP 给药的山羊进食时间更短（P  < 0.01），躺下时间更早（P  < 0.01），躺下时间更长（P  < 0.01），有时，它们会引导它们的脸朝下，闭上眼睛。这些行为反应之后是显着的 ( P < 0.01) 血浆皮质醇 (Cor) 水平增加，这表明山羊经历了压力。在 CDDP 效应的范围内发现了剂量依赖性。在实验 2 中，检查了止吐剂昂丹司琼 (Ond) 预处理的效果。Ond 预处理延长了躺卧潜伏期（P  < 0.01），缩短了躺卧时间（P  < 0.05），降低了血浆 Cor 水平升高的程度（P  < 0.01）。这些结果表明，CDDP 给药通过与催吐物种中呕吐引起的应激相似的生理机制在山羊中产生了某种应激状态。