The sum total of life course exposures creates an exposome that has a significant impact on age-related health. Understanding the interplay between exposome factors and the (epi) genome, offers pertinent insights into the ageing process and its relationship with the accumulation of allostatic load. We propose to exploit this to develop a biomimetic approach that will provide insight into how evolution through natural selection in other species has solved many age related human health issues. In particular, we will emphasise the need to reconnect a more mechanistic approach to medical science with a broader natural sciences approach, using biomimetics to mitigate the global burden of age related ill health. In particular, we will discuss how such an approach indicates leverage of the activities of the Nrf 2 gene to enhance health span via reintroduction of the classical ‘Food as Medicine’ concept, including modulation of the microbiome and the creation of more salutogenic and biophilic environments. Additionally, we will discuss how this approach integrates with novel and developing senotherapies.

中文翻译：

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操纵暴露组以实现更好的老化


生命全程暴露的总和产生的暴露组对与年龄相关的健康具有重大影响。了解暴露组因素和 (epi) 基因组之间的相互作用，可以为衰老过程及其与稳态负荷积累的关系提供相关的见解。我们建议利用这一点来开发一种仿生方法，该方法将深入了解其他物种的自然选择进化如何解决许多与年龄相关的人类健康问题。特别是，我们将强调需要将更机械的医学方法与更广泛的自然科学方法重新联系起来，利用仿生学来减轻与年龄相关的健康不良的全球负担。特别是，我们将讨论这种方法如何表明利用 Nrf 2 基因的活性，通过重新引入经典的“食品作为药物”概念来延长健康寿命，包括调节微生物组和创造更具有益性和亲生物性的环境。此外，我们将讨论这种方法如何与新颖和正在开发的治疗方法相结合。