Exposure to environmental mutagens but also cell-endogenous processes can create DNA double-strand breaks (DSBs) in a cell’s genome. DSBs need to be repaired accurately and timely to ensure genomic integrity and cell survival. One major DSB repair mechanism, called homologous recombination, relies on the nucleolytic degradation of the 5′-terminated strands in a process termed end resection. Here, we review new insights into end resection with a focus on the mechanistic interplay of the nucleases, helicases, and accessory factors involved.

中文翻译：

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同源重组过程中的 DNA 末端切除

暴露于环境诱变剂以及细胞内源性过程可以在细胞基因组中产生 DNA 双链断裂 (DSB)。需要准确及时地修复 DSB，以确保基因组完整性和细胞存活。一种主要的 DSB 修复机制，称为同源重组，依赖于 5' 末端链在称为末端切除的过程中的核酸降解。在这里，我们回顾了对末端切除的新见解，重点是核酸酶、解旋酶和所涉及的辅助因子之间的机制相互作用。