Objective

To evaluate the impact of staying up late (SUL) on the risk of intracranial aneurysm (IA) rupture.

Methods

This case-control study included 452 patients diagnosed with IA. They were divided into ruptured and unruptured groups. Staying up late was categorized in three levels (11–12 o’clock, 12-1 o’clock, after 1 o’clock) according to the time of falling asleep. To explore the relationship between staying up late and risk of IA rupture, univariate and multivariate logistic regression analyses were performed.

Results

Multivariate analysis found a significant difference in the percentage of patients falling asleep at 12-1 o’clock (OR, 2.25; 95% CI, 1.10–4.59) or after 1 o’clock (OR, 4.68; 95% CI, 1.74–12.55) between the ruptured and unruptured groups. The following risk factors differed significantly between the two groups: hypertension (OR, 2.05; 95% CI, 1.33–3.17), current smoking (OR, 1.72; 95% CI, 1.09–2.71), irregular IA (OR, 1.85; 95% CI, 1.15–3.00), IA size ≥8 mm (OR, 1.92; 95% CI, 1.22–3.02), MCA location (OR, 2.45; 95% CI, 1.19–5.02), and aspect ratio (OR, 1.33; 95% CI, 1.02–1.73).

Conclusion

Patients who fell asleep later than 12 midnight on average showed higher risk of IA rupture. The reasons for this are not very clear. A review of the literature suggests that this association may be related to a series of physiological, pathophysiological, endocrine and metabolic changes.

中文翻译：

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熬夜与颅内动脉瘤破裂风险的关系：一项单中心研究

客观的

评估熬夜（SUL）对颅内动脉瘤（IA）破裂风险的影响。

方法

这项病例对照研究包括 452 名诊断为 IA 的患者。他们分为破裂组和未破裂组。熬夜按入睡时间分为三个等级（11-12点、12-1点、1点后）。为了探讨熬夜与 IA 破裂风险之间的关系，进行了单变量和多变量逻辑回归分析。

结果

多变量分析发现，在 12-1 点钟（OR，2.25；95% CI，1.10–4.59）或 1 点钟之后（OR，4.68；95% CI，1.74–）入睡的患者百分比存在显着差异12.55）在破裂组和未破裂组之间。两组之间的以下危险因素有显着差异：高血压（OR，2.05；95% CI，1.33-3.17），当前吸烟（OR，1.72；95% CI，1.09-2.71），不规则 IA（OR，1.85；95 % CI，1.15–3.00），IA 大小 ≥8  mm（OR，1.92；95% CI，1.22–3.02），MCA 位置（OR，2.45；95% CI，1.19–5.02）和纵横比（OR，1.33 ; 95% CI, 1.02–1.73)。

结论

平均在午夜 12 点以后入睡的患者显示出更高的 IA 破裂风险。其原因还不是很清楚。文献回顾表明，这种关联可能与一系列生理、病理生理、内分泌和代谢变化有关。