Background. Interest in electroencephalographic (EEG) coronavirus disease 2019 (COVID-19) findings has been growing, especially in the search for a specific-features EEG of encephalopathy. Methods. We made a retrospective analysis of 29 EEGs recorded in 15 patients with COVID-19 and neurological symptoms. We classified the EEGs as “Acute EEG” and “follow-up EEG.” We did a statistical analysis between voltage and respiratory status of the patient, stay or not in the intensive care unit (ICU), days of stay in the ICU, sedative drugs, pharmacological treatment, type of symptoms predominating, and outcome. Results. We found EEG abnormalities in all patients studied. We observed the amplitude of background <20 µV at 93% of “acute EEG,” versus only 21.4% of “follow-up EEG.” The average voltage went from 12.33 ± 5.09 µV in the acute EEGs to 32.8 ± 20.13 µV in the follow-up EEGs. A total of 60% of acute EEGs showed an intermittent focal rhythmic. We have not found a statistically significant association between voltage of acute EEG and nonneurological clinical status (including respiratory) that may interfere with the EEG findings. Conclusions. Nonspecific diffuse slowing EEG pattern in COVID-19 is the most common finding reported, but we found in addition to that, as a distinctive finding, low voltage EEG, that could explain the low prevalence of epileptic activity published in these patients. A metabolic/hypoxic mechanism seems unlikely on the basis of our EEG findings. This pattern in other etiologies is reminiscent of severe encephalopathy states associated with poor prognosis. However, an unreactive low voltage pattern in COVID-19 patients is not necessarily related to poor prognosis.

背景。对 2019 年脑电图 (EEG) 冠状病毒病 (COVID-19) 发现的兴趣一直在增长，特别是在寻找脑病的特定特征 EEG 方面。方法。我们对 15 名 COVID-19 和神经系统症状患者记录的 29 次脑电图进行了回顾性分析。我们将脑电图分类为“急性脑电图”和“后续脑电图”。我们对患者的电压和呼吸状态、是否入住重症监护病房 (ICU)、入住 ICU 天数、镇静药物、药物治疗、主要症状类型和结果进行了统计分析。结果. 我们发现所有研究患者的脑电图异常。我们观察到 93% 的“急性脑电图”背景幅度 <20 µV，而“后续脑电图”仅为 21.4%。平均电压从急性脑电图中的 12.33 ± 5.09 µV 上升到后续脑电图中的 32.8 ± 20.13 µV。共有 60% 的急性脑电图显示间歇性局灶节律。我们没有发现急性脑电图电压与可能干扰脑电图结果的非神经系统临床状态（包括呼吸系统）之间存在统计学上的显着关联。结论. COVID-19 中的非特异性弥漫性慢脑电图模式是最常见的发现，但除此之外，我们还发现，作为一个独特的发现，低电压脑电图可以解释这些患者中癫痫活动的低患病率。根据我们的脑电图结果，代谢/缺氧机制似乎不太可能。其他病因中的这种模式让人联想到与预后不良相关的严重脑病状态。然而，COVID-19 患者的非反应性低电压模式不一定与预后不良有关。