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Association between polymorphisms of APOB, SLC27A6, AGPAT6 and PRLR genes and milk production and quality traits in goats
Small Ruminant Research ( IF 1.6 ) Pub Date : 2021-07-28 , DOI: 10.1016/j.smallrumres.2021.106484
Adriana Bagatoli 1 , Ana Lúcia Puerro de Melo 2 , Eliane Gasparino 3 , Marcelo Teixeira Rodrigues 4 , Leonardo Ferreira 1 , Odair Scatolin Rossafa Garcia 1 , Maria Amélia Menck Soares 1
Affiliation  

With this study, we aimed to evaluate the association of new and known polymorphisms in the APOB, SLC27A6, AGPAT6, and PRLR genes with goat’s estimated breeding values (EBVs) for milk production and composition traits: lactation length, somatic cell score, total milk yield (kg), and for production (kg) and content of fat, protein, lactose, and solids non-fat. For that, we estimated animal`s EBVs from milk yield and composition data of multiparous Saanen and Alpine goats using a single-trait model. The number of animals used for EBVs estimations varied from 1070 to 1700, depending on the studied trait. For the association analysis, among the animals with EBVs, we genotyped 106 for the APOB/HaeIII polymorphism, 104 for the APOB/SmaI polymorphism, 118 for the Slc27A6/TspRI polymorphism, 245 for the AGPAT6/NcoI polymorphism, 253 for the PLPR/SmaI, and 252 for the PLPR/SfcI polymorphism. We observed that the APOB/HaeIII polymorphism is associated with lactose content, lactation length, and somatic cell score. The APOB/SmaI polymorphism is associated with lactation length, lactose percentage, and total yield of solids non-fat, lactose, protein, fat, and milk. The SLC27A6/TspRI polymorphism is associated with milk lactose content, and the AGPAT6/NcoI polymorphism is associated with lactose yield and milk content of fat, protein, and lactose. In this study, we present new data about the genetic diversity of Brazilian Saanen and Alpine goats and new potential molecular markers for goat milk production and quality traits.



中文翻译:

山羊APOB、SLC27A6、AGPAT6和PRLR基因多态性与产奶质量性状的相关性

通过这项研究,我们旨在评估APOBSLC27A6AGPAT6PRLR基因中新的和已知的多态性与山羊产奶量和成分性状的估计育种值 (EBV) 之间的关联:泌乳时间、体细胞评分、总奶量产量 (kg),以及脂肪、蛋白质、乳糖和非脂肪固体的产量 (kg) 和含量。为此,我们使用单性状模型根据经产的 Saanen 和 Alpine 山羊的产奶量和成分数据估计了动物的 EBV。用于 EBV 估计的动物数量从 1070 到 1700 不等,具体取决于所研究的性状。对于关联分析,在携带 EBV 的动物中,我们对 106 个 APOB/ Hae进行了基因分型III 多态性,APOB/ Sma I 多态性为 104,Slc27A6/ Tsp RI 多态性为 118,AGPAT6/ Nco I 多态性为 245,PLPR/ Sma I多态性为 253,PLPR/ Sfc I 多态性为 252 。我们观察到 APOB/ Hae III 多态性与乳糖含量、泌乳时间和体细胞评分相关。APOB/ Sma I 多态性与泌乳时间、乳糖百分比和非脂肪固体、乳糖、蛋白质、脂肪和牛奶的总产量有关。SLC27A6/ Tsp RI 多态性与牛奶乳糖含量有关,而 AGPAT6/ NcoI 多态性与乳糖产量和脂肪、蛋白质和乳糖的乳含量有关。在这项研究中,我们提供了有关巴西萨能山羊和高山山羊遗传多样性的新数据以及山羊产奶量和质量性状的新潜在分子标记。

更新日期:2021-08-09
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