Macrophages are primarily known as phagocytic innate immune cells, but are, in fact, highly dynamic multi-taskers that interact with many different tissue types and have regulatory roles in development, homeostasis, tissue repair, and disease. In all of these scenarios angiogenesis is pivotal and macrophages appear to play a key role in guiding both blood vessel sprouting and remodelling wherever that occurs. Recent studies have explored these processes in a diverse range of models utilising the complementary strengths of rodent, fish and tissue culture studies to unravel the mechanisms underlying these interactions and regulatory functions. Here we discuss how macrophages regulate angiogenesis and its resolution as embryonic tissues grow, as well as their parallel and different functions in repairing wounds and in pathologies, with a focus on chronic wounds and cancer.

巨噬细胞主要被称为吞噬性先天免疫细胞，但实际上是高度动态的多任务细胞，可与许多不同的组织类型相互作用，并在发育、体内平衡、组织修复和疾病中发挥调节作用。在所有这些情况下，血管生成都是关键，巨噬细胞似乎在指导血管发芽和重塑中发挥关键作用。最近的研究利用啮齿动物、鱼类和组织培养研究的互补优势在各种模型中探索了这些过程，以揭示这些相互作用和调节功能背后的机制。在这里，我们讨论巨噬细胞如何在胚胎组织生长时调节血管生成及其消退，以及它们在修复伤口和病理中的平行和不同功能，