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Computational model of trachea-alveoli gas movement during spontaneous breathing
Respiratory Physiology & Neurobiology ( IF 2.3 ) Pub Date : 2021-07-28 , DOI: 10.1016/j.resp.2021.103767
L D Jiménez-Posada 1 , Juan C Maya 2 , M Sánchez-Ocampo 1 , S López-Isaza 1 , S Cortes-Ospina 1 , Y J Montagut-Ferizzola 1 , R Torres 1
Affiliation  

A computational model of the transport of gases involved in spontaneous breathing, from the trachea inlet to the alveoli was developed for healthy patients. Convective and diffusive transport mechanisms were considered simultaneously, using a diffusion coefficient (D) that has considered the four main species of gases present in the exchange carried out by the human lung, nitrogen (N2), oxygen (O2), carbon dioxide (CO2) and water vapor (H2O). A Matlab® script was programmed to simulate the trachea-alveolus gas exchange model under three respiratory frequencies: 12, 24 and 40 breaths per minute (BPM), each with three diaphragmatic movements of 2 cm, 4 cm, and 6 cm. During the simulations, the CO2 inlet concentrations in the alveoli and the O2 concentration at the inlet of the trachea were kept constant. A simplified but stable model of mass transport between the trachea and alveoli was obtained, allowing the concentrations to be determined dynamically at the selected test points in the airway.



中文翻译:

自主呼吸时气管-肺泡气体运动的计算模型

为健康患者开发了一种涉及自主呼吸的气体从气管入口到肺泡运输的计算模型。使用扩散系数 (D) 同时考虑了对流和扩散传输机制,该扩散系数考虑了人类肺进行的交换中存在的四种主要气体种类:氮气 (N 2 )、氧气 (O 2 )、二氧化碳(CO 2 ) 和水蒸气 (H 2 O)。编写了一个 Matlab® 脚本来模拟三种呼吸频率下的气管-肺泡气体交换模型:每分钟 12、24 和 40 次呼吸 (BPM),每种都有 2 厘米、4 厘米和 6 厘米的三个横膈膜运动。在模拟过程中,CO 2肺泡入口浓度和气管入口O 2浓度保持恒定。获得了一个简化但稳定的气管和肺泡之间的质量传输模型,允许在气道中选定的测试点动态确定浓度。

更新日期:2021-08-05
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