Primary central sleep apnea (CSA) is classified as non-hypercapnic CSA. High loop gain, lower carbon dioxide (CO₂) reserves, and other reasons can lead to hypocapnia in patients who develop intermittent hyperventilation during sleep. Therefore, it is necessary to monitor nocturnal CO₂ level for these patients. We report a female patient diagnosed with non-hypercapnic primary CSA who complained of snoring, apnea, and excessive daytime sleepiness. With the monitoring of transcutaneous partial pressure of CO₂ (PtcCO₂), manual non-invasive ventilation (NIV) pressure titration was performed with continuous positive airway pressure (CPAP), bilevel positive airway pressure in a spontaneous-timed mode (BPAP-ST), and adaptive servo-ventilation (ASV) mode for three nights, respectively. Only ASV mode could stabilize the PtcCO₂ above the apneic threshold (AT, approximately 40 mmHg) with successfully eliminating central apnea events. It is concluded that the level of CO₂ is the determinant of successful NIV pressure titration in patients with non-hypercapnic CSA.

原发性中枢性睡眠呼吸暂停 (CSA) 被归类为非高碳酸血症 CSA。高环路增益、较低的二氧化碳 (CO ₂ ) 储备和其他原因可能导致在睡眠期间出现间歇性过度通气的患者出现低碳酸血症。因此，有必要监测这些患者的夜间CO ₂水平。我们报告了一名被诊断为非高碳酸血症原发性 CSA 的女性患者，她抱怨打鼾、呼吸暂停和白天过度嗜睡。随着经皮CO ₂分压（PtcCO ₂)、手动无创通气 (NIV) 压力滴定，采用持续气道正压通气 (CPAP)、自发定时双水平气道正压通气 (BPAP-ST) 和自适应伺服通气 (ASV) 模式进行三种晚上，分别。只有 ASV 模式才能将 PtcCO ₂稳定在呼吸暂停阈值（AT，大约 40 mmHg）以上，并成功消除中枢性呼吸暂停事件。得出的结论是，CO ₂水平是非高碳酸血症 CSA 患者 NIV 压力滴定成功的决定因素。