An efficient copper-catalyzed tandem oxidation/nitroaldol reaction of hydroxyl compounds with nucleophiles is developed. In this work, β-nitro-α-hydroxy esters were prepared via cross-dehydrogenative coupling reaction using α-hydroxy esters as hydroxy compounds and nitromethane as a nucleophile. The reaction is believed to undergo an oxidation of the hydroxy group and then an addition of the generated carbonyl group. It is an example of CDC reactions related to hydroxy compounds via carbonyl intermediates.

中文翻译：

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α-羟基酯与硝基甲烷的铜催化交叉脱氢偶联

开发了羟基化合物与亲核试剂的有效铜催化串联氧化/硝基醛醇反应。在这项工作中，β-硝基-α-羟基酯是通过交叉脱氢偶联反应制备的，使用α-羟基酯作为羟基化合物，硝基甲烷作为亲核试剂。据信该反应经历羟基的氧化，然后产生的羰基的加成。它是通过羰基中间体与羟基化合物相关的 CDC 反应的一个例子。