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Metabolic syndrome is not associated to an increased risk of low bone mineral density in men at risk for osteoporosis
Journal of Endocrinological Investigation ( IF 3.9 ) Pub Date : 2021-07-27 , DOI: 10.1007/s40618-021-01638-w
D Rendina 1 , L D'Elia 1 , G De Filippo 2 , V Abate 1 , M Evangelista 1 , A Giaquinto 1 , B Barone 3 , G Piccinocchi 4 , D Prezioso 3 , P Strazzullo 1
Affiliation  

Purpose

We have recently demonstrated a significant association between osteoporosis (Op) and metabolic syndrome (MetS) in Caucasian women examined by Dual-energy X-ray absorptiometry (DXA) for suspected Op. This cross-sectional study was performed to evaluate the association between MetS and Op in Caucasian men enrolled in the same geographical area, with identical criteria and in the same time range.

Methods

Among subjects enrolled in the SIMON study, we selected the medical records of all free-living men who performed a contextual evaluation of both bone mineral density (BMD) by DXA and MetS constitutive elements (arterial blood pressure, waist circumference, serum levels of triglycerides, high-density lipoprotein cholesterol, and fasting glucose). All enrolled subjects refer to “COMEGEN” general practitioners’ cooperative operating in Naples, Southern Italy.

Results

Overall, the medical records of 880 men were examined. No significant association between MetS and Op was observed. Among MetS constitutive elements, waist circumference was inversely related to Op risk.

Conclusion

In Caucasian men examined by DXA for suspected Op, no significant association was observed between Op and MetS. The study results contrast to those observed in women enrolled in the same geographical area, with identical criteria and in the same time range and may be related to sexual dimorphism occurring in clinical expressiveness of both MetS and Op.



中文翻译:

代谢综合征与有骨质疏松症风险的男性低骨密度风险增加无关

目的

我们最近通过双能 X 射线骨密度仪 (DXA) 检查疑似 Op 的高加索女性骨质疏松症 (Op) 和代谢综合征 (MetS) 之间存在显着关联。这项横断面研究旨在评估在相同地理区域、相同标准和相同时间范围内注册的高加索男性的 MetS 和 Op 之间的关联。

方法

在参加 SIMON 研究的受试者中,我们选择了所有自由生活男性的医疗记录,他们通过 DXA 和 MetS 构成要素(动脉血压、腰围、血清甘油三酯水平)对骨矿物质密度 (BMD) 进行了上下文评估、高密度脂蛋白胆固醇和空腹血糖)。所有入选对象均指在意大利南部那不勒斯开展的“COMEGEN”全科医生合作社。

结果

总体而言,检查了 880 名男性的医疗记录。没有观察到 MetS 和 Op 之间的显着关联。在 MetS 构成要素中,腰围与 Op 风险呈负相关。

结论

在 DXA 检查疑似 Op 的高加索男性中,未观察到 Op 和 MetS 之间存在显着关联。该研究结果与在相同地理区域、相同标准和相同时间范围内登记的女性中观察到的结果形成对比,并且可能与 MetS 和 Op 的临床表现中发生的性别二态性有关。

更新日期:2021-07-27
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