No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants.,The American Journal of Gastroenterology

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No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants.
The American Journal of Gastroenterology ( IF 9.8 ) Pub Date : 2021-11-01 , DOI: 10.14309/ajg.0000000000001377
Qiangsheng He _{1,

2} , Bin Xia _{1,

2} , Wenbo Meng ₃ , Die Fan ₂ , Zi-Chong Kuo ₄ , Junjie Huang ₅ , Xiwen Qin _{6,

7,

8} , Huachun Zou _{9,

10} , Yulong He _{1,

4} , Changhua Zhang ₄ , Shuo Fang ₁₁ , Yihang Pan _{1,

4} , Man Yang _{3,

4} , Jinqiu Yuan _{1,

2,

4}

Affiliation

Big Data Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
Clinical Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Guangdong Provincial Key Laboratory of Gastrointestinal Cancers, Center for Digestive Disease, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.
JC School of Public Health, The Chinese University of Hong Kong, Shatin, Hong Kong.
Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Science, Monash University, Melbourne, Australia.
Victorian Heart Institute, Monash University, Melbourne, Australia.
School of Population and Global Health, Faculty of Medicine, Density and Health Sciences, University of Western Australia, Perth, Australia.
School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China.
Kirby Institute, University of New South Wales, Sydney, Australia.
Department of Oncology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.

INTRODUCTION The association between proton pump inhibitors' (PPIs) use and mortality remains unclear. METHODS This was a prospective analysis of 440,840 UK residents and 13,154 deaths. We evaluated the associations with multivariate Cox regression. RESULTS After adjusting for confounders, such as over health status and longstanding diseases, the regular use of PPIs was not associated with an increased risk of all-cause mortality and mortality due to neoplasms, circulatory system diseases, respiratory system diseases, digestive system diseases, external causes, and other causes. DISCUSSION Regular use of PPIs was not associated with an increased risk of all-cause and cause-specific mortality.

中文翻译：

定期使用质子泵抑制剂与全因和特定原因死亡风险之间没有关联：基于人口的 44 万参与者队列。

引言质子泵抑制剂（PPI）的使用与死亡率之间的关系仍不清楚。方法这是对 440,840 名英国居民和 13,154 名死亡人数的前瞻性分析。我们评估了与多元 Cox 回归的关联。结果在调整了诸如过度健康状况和长期疾病等混杂因素后，定期使用质子泵抑制剂与全因死亡率和肿瘤、循环系统疾病、呼吸系统疾病、消化系统疾病、外部原因和其他原因。讨论定期使用 PPI 与全因和特定原因死亡率风险增加无关。

更新日期：2021-07-27

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