OBJECTIVE Although myriad researches upon the associations between LncRNA H19 polymorphic variants (rs2839698 G>A, rs217727 G>A, rs2107425 C>T, rs2735971 A>G and rs3024270 C>G) and the susceptibility to cancer have been conducted, these results remained contradictory and perplexing. Basing on that, a systematic review and updated meta-analysis was performed to anticipate a fairly precise assessment about such associations. METHODS We retrieved the electronic databases EMBASE, PubMed and Web of Science for valuable academic studies before February 28, 2021. Ultimately, 28 of which were encompassed after screening in this meta-analysis, and the available data was extracted and integrated. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) was used to evaluate such associations. For multi-level investigation, subgroup analysis derived from source of controls together with genotypic method was preformed. RESULTS Eventually, 28 articles altogether embodying 57 studies were included in this meta-analysis. The results illuminated that LncRNA H19 polymorphisms mentioned above were all irrelevant to cancer susceptibility. Nevertheless, crucial results were found concentrated in population-based control group when subgroup analysis by source of controls were performed in H19 mutation rs2839698 and rs2735971. Meanwhile, in the stratification analysis by genotypic method, apparent cancer risks were discovered by TaqMan method in H19 mutation rs2107425 and rs3024270. Then, trial sequential analysis demonstrated that the results about such associations were firm evidence of effect. CONCLUSION Therefore, this meta-analysis indicated that LncRNA H19 polymorphisms were not associated with the susceptibility to human cancer. However, after the stratification analysis, inconsistent results still existed in different genotypic method and source of control. Thus, more high-quality studies on cancer patients of different factors were needed to confirm these findings.

中文翻译：

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LncRNA H19 多态性变异对癌症易感性的影响：28 项病例对照研究的系统回顾和更新荟萃分析。

目的 尽管对 LncRNA H19 多态性变异（rs2839698 G>A、rs217727 G>A、rs2107425 C>T、rs2735971 A>G 和 rs3024270 C>G）与癌症易感性之间的关联进行了大量研究，但这些结果仍然存在矛盾且令人困惑。在此基础上，进行了系统回顾和更新的荟萃分析，以预测对此类关联的相当精确的评估。方法我们检索了2021年2月28日之前的电子数据库EMBASE、PubMed和Web of Science进行有价值的学术研究。最终，经过本次荟萃分析筛选，纳入了其中28个数据库，并对现有数据进行了提取和整合。使用具有 95% 置信区间 (CI) 的合并比值比 (OR) 来评估此类关联。对于多层次的调查，进行了来自对照来源的亚组分析以及基因型方法。结果 最终，本次荟萃分析纳入了 28 篇文章，共涉及 57 项研究。结果表明，上述LncRNA H19多态性均与癌症易感性无关。然而，当对 H19 突变 rs2839698 和 rs2735971 进行按对照来源进行亚组分析时，发现关键结果集中在基于人群的对照组。同时，在基因型方法的分层分析中，通过TaqMan方法在H19突变rs2107425和rs3024270中发现了明显的癌症风险。然后，试验序贯分析表明，这种关联的结果是效果的有力证据。结论 因此，这项荟萃分析表明，LncRNA H19 多态性与人类癌症的易感性无关。但分层分析后，不同基因型方法和对照源仍存在结果不一致的情况。因此，需要对不同因素的癌症患者进行更多高质量的研究来证实这些发现。