Past investigations utilizing diffusion tensor imaging (DTI) have demonstrated that cocaine use disorder (CUD) yields white matter changes, primarily in the corpus callosum. By applying Bayesian model averaging using multiple linear regression in DTI, we demonstrate there may exist relationships between the impaired white matter and glutamic acid decarboxylase (GAD) polymorphisms. This work explored the two-way and three-way interactions between GAD1a (SNP: rs1978340) and GAD1b (SNP: rs769390) polymorphisms and years of cocaine use (YCU). GAD1a was associated with more frontal white matter changes on its own but GAD1b was associated with more midbrain and cerebellar changes as well as a greater increase in white matter changes in the context of chronic cocaine use. The three-way interaction GAD1a|GAD1b|YCU appeared to be roughly an average of the polymorphism two-way interactions GAD1a|YCU and GAD1b|YCU. The three-way interaction demonstrated multiple regions including corpus callosum which featured fewer significant voxel changes, perhaps suggesting a small protective effect of having both polymorphisms on corpus callosum and cerebellar peduncle.

中文翻译：

---

使用贝叶斯模型平均法探索白质完整性、可卡因使用和 GAD 多态性之间的关系。


过去利用扩散张量成像 (DTI) 的研究表明，可卡因使用障碍 (CUD) 会导致白质变化，主要是在胼胝体。通过在 DTI 中应用多重线性回归的贝叶斯模型平均，我们证明受损的白质和谷氨酸脱羧酶 (GAD) 多态性之间可能存在关系。这项工作探讨了 GAD1a (SNP: rs1978340) 和 GAD1b (SNP: rs769390) 多态性与可卡因使用年限 (YCU) 之间的双向和三向相互作用。 GAD1a 本身与更多的额叶白质变化相关，但 GAD1b 与更多的中脑和小脑变化以及长期使用可卡因情况下白质变化的更大增加相关。三向相互作用 GAD1a|GAD1b|YCU 似乎大致是多态性双向相互作用 GAD1a|YCU 和 GAD1b|YCU 的平均值。三向相互作用证明了包括胼胝体在内的多个区域具有较少的显着体素变化，这可能表明同时具有多态性对胼胝体和小脑脚具有较小的保护作用。