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Urinary soluble (pro)renin receptor excretion is associated with urine pH in humans.
PLOS ONE ( IF 2.9 ) Pub Date : 2021-07-26 , DOI: 10.1371/journal.pone.0254688
Nobukazu Sasaki 1 , Satoshi Morimoto 1 , Chikahito Suda 1 , Satoru Shimizu 2 , Atsuhiro Ichihara 1
Affiliation  

The (pro)renin receptor [(P)RR] binds to renin and its precursor prorenin to activate the tissue renin-angiotensin system. It is cleaved to generate soluble (P)RR and M8-9, a residual hydrophobic truncated protein. The (pro)renin receptor also functions as an intracellular accessory protein of vacuolar-type H+-ATPase, which plays an essential role in controlling the intracellular vesicular acid environment. Thus, in the kidney, (P)RR may play a role in transporting H+ to urine in the collecting duct. Although blood soluble (P)RR has been recognized as a biomarker reflecting the status of the tissue renin-angiotensin system and/or tissue (P)RR, the significance of urinary soluble (P)RR excretion has not been determined. Therefore, this study aimed to investigate the characteristics of urinary soluble (P)RR excretion. Urinary soluble (P)RR excretion was measured, and its association with background factors was investigated in 441 patients. Relationships between changes in urine pH due to vitamin C treatment, which reduce urine pH, and urinary soluble (P)RR excretion were investigated in 10 healthy volunteers. Urinary soluble (P)RR excretion was 1.46 (0.44-2.92) ng/gCre. Urine pH showed a significantly positive association with urinary soluble (P)RR excretion, independent of other factors. Changes in urine pH and urinary soluble (P)RR excretion due to vitamin C treatment were significantly and positively correlated (ρ = 0.8182, p = 0.0038). These data showed an association between urinary soluble (P)RR excretion and urine pH in humans, suggesting that (P)RR in the kidney might play a role in urine pH regulation.

中文翻译:

尿液可溶性(原)肾素受体排泄与人体尿液 pH 值有关。

(原)肾素受体 [(P)RR] 与肾素及其前体肾素原结合以激活组织肾素-血管紧张素系统。它被裂解产生可溶性 (P)RR 和 M8-9,一种残留的疏水性截短蛋白。(原)肾素受体还作为液泡型 H+-ATP 酶的细胞内辅助蛋白发挥作用,在控制细胞内囊泡酸环境中起重要作用。因此,在肾脏中,(P)RR 可能在将 H+ 运输到集合管中的尿液中发挥作用。尽管血液可溶性 (P)RR 已被公认为反映组织肾素-血管紧张素系统和/或组织 (P)RR 状态的生物标志物,但尿可溶性 (P)RR 排泄的重要性尚未确定。因此,本研究旨在研究尿可溶性 (P)RR 排泄的特征。测量了尿可溶性 (P) RR 排泄,并在 441 名患者中研究了其与背景因素的关联。在 10 名健康志愿者中研究了维生素 C 治疗引起的尿液 pH 值变化(降低尿液 pH 值)与尿可溶性 (P)RR 排泄之间的关系。尿可溶性 (P)RR 排泄量为 1.46 (0.44-2.92) ng/gCre。尿液 pH 值与尿可溶性 (P)RR 排泄呈显着正相关,与其他因素无关。由于维生素 C 治疗,尿液 pH 值和尿可溶性 (P)RR 排泄的变化呈显着正相关(ρ = 0.8182,p = 0.0038)。这些数据显示人体尿液中可溶性 (P)RR 排泄与尿液 pH 值之间存在关联,表明肾脏中的 (P)RR 可能在尿液 pH 调节中发挥作用。并在 441 名患者中研究了其与背景因素的关联。在 10 名健康志愿者中研究了维生素 C 治疗引起的尿液 pH 值变化(降低尿液 pH 值)与尿可溶性 (P)RR 排泄之间的关系。尿可溶性 (P)RR 排泄量为 1.46 (0.44-2.92) ng/gCre。尿液 pH 值与尿可溶性 (P)RR 排泄呈显着正相关,与其他因素无关。由于维生素 C 治疗,尿液 pH 值和尿可溶性 (P)RR 排泄的变化呈显着正相关(ρ = 0.8182,p = 0.0038)。这些数据显示人体尿液中可溶性 (P)RR 排泄与尿液 pH 值之间存在关联,表明肾脏中的 (P)RR 可能在尿液 pH 调节中发挥作用。并在 441 名患者中研究了其与背景因素的关联。在 10 名健康志愿者中研究了维生素 C 治疗引起的尿液 pH 值变化(降低尿液 pH 值)与尿可溶性 (P)RR 排泄之间的关系。尿可溶性 (P)RR 排泄量为 1.46 (0.44-2.92) ng/gCre。尿液 pH 值与尿可溶性 (P)RR 排泄呈显着正相关,与其他因素无关。由于维生素 C 治疗,尿液 pH 值和尿可溶性 (P)RR 排泄的变化呈显着正相关(ρ = 0.8182,p = 0.0038)。这些数据显示人体尿液中可溶性 (P)RR 排泄与尿液 pH 值之间存在关联,表明肾脏中的 (P)RR 可能在尿液 pH 调节中发挥作用。在 10 名健康志愿者中研究了维生素 C 治疗引起的尿液 pH 值变化(降低尿液 pH 值)与尿可溶性 (P)RR 排泄之间的关系。尿可溶性 (P)RR 排泄量为 1.46 (0.44-2.92) ng/gCre。尿液 pH 值与尿可溶性 (P)RR 排泄呈显着正相关,与其他因素无关。由于维生素 C 治疗,尿液 pH 值和尿可溶性 (P)RR 排泄的变化呈显着正相关(ρ = 0.8182,p = 0.0038)。这些数据显示人体尿液中可溶性 (P)RR 排泄与尿液 pH 值之间存在关联,表明肾脏中的 (P)RR 可能在尿液 pH 调节中发挥作用。在 10 名健康志愿者中研究了维生素 C 治疗引起的尿液 pH 值变化(降低尿液 pH 值)与尿可溶性 (P)RR 排泄之间的关系。尿可溶性 (P)RR 排泄量为 1.46 (0.44-2.92) ng/gCre。尿液 pH 值与尿可溶性 (P)RR 排泄呈显着正相关,与其他因素无关。由于维生素 C 治疗,尿液 pH 值和尿可溶性 (P)RR 排泄的变化呈显着正相关(ρ = 0.8182,p = 0.0038)。这些数据显示人体尿液中可溶性 (P)RR 排泄与尿液 pH 值之间存在关联,表明肾脏中的 (P)RR 可能在尿液 pH 调节中发挥作用。92) 纳克/克。尿液 pH 值与尿可溶性 (P)RR 排泄呈显着正相关,与其他因素无关。由于维生素 C 治疗,尿液 pH 值和尿可溶性 (P)RR 排泄的变化呈显着正相关(ρ = 0.8182,p = 0.0038)。这些数据显示人体尿液中可溶性 (P)RR 排泄与尿液 pH 值之间存在关联,表明肾脏中的 (P)RR 可能在尿液 pH 调节中发挥作用。92) 纳克/克。尿液 pH 值与尿可溶性 (P)RR 排泄呈显着正相关,与其他因素无关。由于维生素 C 治疗,尿液 pH 值和尿可溶性 (P)RR 排泄的变化呈显着正相关(ρ = 0.8182,p = 0.0038)。这些数据显示人体尿液中可溶性 (P)RR 排泄与尿液 pH 值之间存在关联,表明肾脏中的 (P)RR 可能在尿液 pH 调节中发挥作用。
更新日期:2021-07-26
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