We present a case report that shows an abscopal effect in the context of a safety and efficacy clinical trial for histotripsy as ablation technique in liver tumors. The abscopal effect appears in the form of reduction in the volume of nontreated tumor lesions in the same organ, as well as sustained reduction of tumor marker [carcinoembryonic antigen (CEA)] that extends weeks away of the procedure. Histotripsy is a novel noninvasive, nonthermal, and nonionizing precise ablation technique for tissue destruction guided by ultrasonography. We discuss the feasibility of this technique compared with other focal therapies and its possibilities as immune system enhancer.

中文翻译：

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肝组织切除术介导的远隔效应病例报告。

我们提供了一份病例报告，该报告显示了在肝脏肿瘤中作为消融技术的组织切除术的安全性和有效性临床试验背景下的远隔效应。远隔效应表现为同一器官中未治疗的肿瘤病变体积减少，以及肿瘤标志物 [癌胚抗原 (CEA)] 持续减少，持续减少数周后的手术。Histotripsy 是一种新型的无创、非热和非电离精确消融技术，用于在超声引导下进行组织破坏。我们讨论了该技术与其他局部疗法相比的可行性及其作为免疫系统增强剂的可能性。