The Phenotypic/Genotypic Profile of OXA-10-like harboring, Carbapenem-Resistant Pseudomonas aeruginosa: Using Validated Pharmacokinetic/Pharmacodynamic in vivo Models to Further Evaluate Enzyme Functionality and Clinical Implications,Antimicrobial Agents and Chemotherapy

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The Phenotypic/Genotypic Profile of OXA-10-like harboring, Carbapenem-Resistant Pseudomonas aeruginosa: Using Validated Pharmacokinetic/Pharmacodynamic in vivo Models to Further Evaluate Enzyme Functionality and Clinical Implications
Antimicrobial Agents and Chemotherapy ( IF 4.1 ) Pub Date : 2021-07-26 , DOI: 10.1128/aac.01274-21
Christian M Gill ₁ , Adrian Brink ₂ , Chun Yat Chu ₂ , Jennifer Coetzee ₃ , George Dimopoulos ₄ , Clinton Moodley ₂ , Christoffel Johannes Opperman ₂ , Spyros Pournaras ₅ , Fred C Tenover ₆ , Isabella A Tickler ₆ , Hafsah Deepa Tootla ₂ , Sophia Vourli ₅ , David P Nicolau _{1,

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Affiliation

In vitro MICs and in vivo pharmacodynamics of ceftazidime and cefepime human-simulated regimens (HSR) against mCIM-positive P. aeruginosa harboring different OXA-10-like subtypes were described. The murine thigh model assessed ceftazidime (2g q8h HSR) and ...

中文翻译：

OXA-10 样窝藏、耐碳青霉烯类铜绿假单胞菌的表型/基因型谱：使用经过验证的体内药代动力学/药效学模型进一步评估酶功能和临床意义

描述了头孢他啶和头孢吡肟人模拟方案 (HSR) 针对具有不同 OXA-10 样亚型的 mCIM 阳性铜绿假单胞菌的体外 MIC 和体内药效学。小鼠大腿模型评估了头孢他啶（2g q8h HSR）和...

更新日期：2021-09-12

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