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Four-Component Synthesis of Functionalized 1,3,4-Oxadiazole Derivatives Bearing the 2-Amino
Heterocycles ( IF 0.6 ) Pub Date : 2021-07-27 , DOI: 10.3987/com-21-14504
Bita Mohtat , Milad Bazaz Rastkar , Gholam Bagheri Marandi , Hoorieh Djahaniani

A one-pot sixteen derivatives of N-((5-(aryl)-4H-pyrazol-3-yl)(aryl)methyl)benzo[d]thiazol-2-amine (5a–p) were synthesized from 2-aminobezothiazole, aromatic aldehyde, N-isocyaniminotriphenylphosphorane on reaction with aryl carboxylic acid derivatives under a catalyst-free condition in CH2Cl2 by a Ugi-4CR/aza-Wittig cyclization at room temperature in fairly good yields. The newly synthesized compounds were confirmed and deduced based on IR, 1H NMR, 13C NMR, and mass spectroscopy, and elemental analysis.

中文翻译:

带有 2-氨基的官能化 1,3,4-恶二唑衍生物的四组分合成

从 2-氨基苯并噻唑合成了 N-((5-(芳基)-4H-吡唑-3-基)(芳基)甲基)苯并[d]噻唑-2-胺( 5a-p )的一锅十六衍生物,芳香醛,N-异氰基亚氨基三苯基正膦在无催化剂条件下在CH 2 Cl 2 中通过Ugi-4CR/氮杂-Wittig环化在室温下以相当好的产率与芳基羧酸衍生物反应。新合成的化合物经红外光谱、1 H NMR、13 C NMR、质谱和元素分析证实和推导
更新日期:2021-07-27
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