Autophagy is a conserved degradation process crucial to maintaining the primary function of cellular and organismal metabolism. Impaired autophagy could develop numerous diseases, including cancer, cardiomyopathy, neurodegenerative disorders, and aging. N6-methyladenosine (m6A) is the most common RNA modification in eukaryotic cells, and the fate of m6A modified transcripts is controlled by m6A RNA binding proteins. m6A modification influences mRNA alternative splicing, stability, translation, and subcellular localization. Intriguingly, recent studies show that m6A RNA methylation could alter the expression of essential autophagy-related (ATG) genes and influence the autophagy function. Thus, both m6A modification and autophagy could play a crucial role in the onset and progression of various human diseases. In this review, we summarize the latest studies describing the impact of m6A modification in autophagy regulation and discuss the role of m6A modification-autophagy axis in different human diseases, including obesity, heart disease, azoospermatism or oligospermatism, intervertebral disc degeneration, and cancer. The comprehensive understanding of the m6A modification and autophagy interplay may help in interpreting their impact on human diseases and may aid in devising future therapeutic strategies.

中文翻译：

---

当前对 m6A RNA 甲基化和自噬相互作用在人类疾病中的影响的见解

自噬是一种保守的降解过程，对于维持细胞和机体代谢的主要功能至关重要。自噬受损可能会导致多种疾病，包括癌症、心肌病、神经退行性疾病和衰老。N6-甲基腺苷 (m6A) 是真核细胞中最常见的 RNA 修饰，m6A 修饰转录物的命运由 m6A RNA 结合蛋白控制。m6A 修饰影响 mRNA 可变剪接、稳定性、翻译和亚细胞定位。有趣的是，最近的研究表明 m6A RNA 甲基化可以改变基本自噬相关 (ATG) 基因的表达并影响自噬功能。因此，m6A 修饰和自噬都可以在各种人类疾病的发生和发展中发挥关键作用。在这次审查中，我们总结了描述 m6A 修饰对自噬调节影响的最新研究，并讨论了 m6A 修饰-自噬轴在不同人类疾病中的作用，包括肥胖、心脏病、无精子症或少精子症、椎间盘退变和癌症。对 m6A 修饰和自噬相互作用的全面理解可能有助于解释它们对人类疾病的影响，并可能有助于制定未来的治疗策略。