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Association of dyslipidemia with the severity and mortality of coronavirus disease 2019 (COVID-19): a meta-analysis
Virology Journal ( IF 4.0 ) Pub Date : 2021-07-27 , DOI: 10.1186/s12985-021-01604-1
Yanli Liu 1 , Yilong Pan 1 , Yuyao Yin 1 , Wenhao Chen 1 , Xiaodong Li 1
Affiliation  

The numbers of confirmed cases of coronavirus disease 2019 (COVID-19) and COVID-19 related deaths are still increasing, so it is very important to determine the risk factors of COVID-19. Dyslipidemia is a common complication in patients with COVID-19, but the association of dyslipidemia with the severity and mortality of COVID-19 is still unclear. The aim of this study is to analyze the potential association of dyslipidemia with the severity and mortality of COVID-19. We searched the PubMed, Embase, MEDLINE, and Cochrane Library databases for all relevant studies up to August 24, 2020. All the articles published were retrieved without language restriction. All analysis was performed using Stata 13.1 software and Mantel–Haenszel formula with fixed effects models was used to compare the differences between studies. The Newcastle Ottawa scale was used to assess the quality of the included studies. Twenty-eight studies involving 12,995 COVID-19 patients were included in the meta-analysis, which was consisted of 26 cohort studies and 2 case–control studies. Dyslipidemia was associated with the severity of COVID-19 (odds ratio [OR] = 1.27, 95% confidence interval [CI] 1.11–1.44, P = 0.038, I2 = 39.8%). Further, patients with dyslipidemia had a 2.13-fold increased risk of death compared to patients without dyslipidemia (95% CI 1.84–2.47, P = 0.001, I2 = 66.4%). The results proved that dyslipidemia is associated with increased severity and mortality of COVID-19. Therefore, we should monitor blood lipids and administer active treatments in COVID-19 patients with dyslipidemia to reduce the severity and mortality.

中文翻译:

血脂异常与 2019 年冠状病毒病 (COVID-19) 严重程度和死亡率的关联:一项荟萃分析

2019 冠状病毒病 (COVID-19) 确诊病例和 COVID-19 相关死亡人数仍在增加,因此确定 COVID-19 的危险因素非常重要。血脂异常是 COVID-19 患者的常见并发症,但血脂异常与 COVID-19 的严重程度和死亡率的关联仍不清楚。本研究的目的是分析血脂异常与 COVID-19 的严重程度和死亡率之间的潜在关联。我们检索了 PubMed、Embase、MEDLINE 和 Cochrane 图书馆数据库中截至 2020 年 8 月 24 日的所有相关研究。所有发表的文章均不受语言限制地检索。所有分析均使用 Stata 13.1 软件进行,并使用 Mantel-Haenszel 公式和固定效应模型来比较研究之间的差异。纽卡斯尔渥太华量表用于评估纳入研究的质量。荟萃分析包括 28 项涉及 12,995 名 COVID-19 患者的研究,其中包括 26 项队列研究和 2 项病例对照研究。血脂异常与 COVID-19 的严重程度相关(优势比 [OR] = 1.27,95% 置信区间 [CI] 1.11–1.44,P = 0.038,I2 = 39.8%)。此外,与没有血脂异常的患者相比,血脂异常患者的死亡风险增加了 2.13 倍(95% CI 1.84–2.47,P = 0.001,I2 = 66.4%)。结果证明,血脂异常与 COVID-19 的严重程度和死亡率增加有关。因此,我们应监测血脂并积极治疗 COVID-19 血脂异常患者,以降低严重程度和死亡率。荟萃分析包括 28 项涉及 12,995 名 COVID-19 患者的研究,其中包括 26 项队列研究和 2 项病例对照研究。血脂异常与 COVID-19 的严重程度相关(优势比 [OR] = 1.27,95% 置信区间 [CI] 1.11–1.44,P = 0.038,I2 = 39.8%)。此外,与没有血脂异常的患者相比,血脂异常患者的死亡风险增加了 2.13 倍(95% CI 1.84–2.47,P = 0.001,I2 = 66.4%)。结果证明,血脂异常与 COVID-19 的严重程度和死亡率增加有关。因此,我们应监测血脂并积极治疗 COVID-19 血脂异常患者,以降低严重程度和死亡率。荟萃分析包括 28 项涉及 12,995 名 COVID-19 患者的研究,其中包括 26 项队列研究和 2 项病例对照研究。血脂异常与 COVID-19 的严重程度相关(优势比 [OR] = 1.27,95% 置信区间 [CI] 1.11–1.44,P = 0.038,I2 = 39.8%)。此外,与没有血脂异常的患者相比,血脂异常患者的死亡风险增加了 2.13 倍(95% CI 1.84–2.47,P = 0.001,I2 = 66.4%)。结果证明,血脂异常与 COVID-19 的严重程度和死亡率增加有关。因此,我们应监测血脂并积极治疗 COVID-19 血脂异常患者,以降低严重程度和死亡率。由 26 项队列研究和 2 项病例对照研究组成。血脂异常与 COVID-19 的严重程度相关(优势比 [OR] = 1.27,95% 置信区间 [CI] 1.11–1.44,P = 0.038,I2 = 39.8%)。此外,与没有血脂异常的患者相比,血脂异常患者的死亡风险增加了 2.13 倍(95% CI 1.84–2.47,P = 0.001,I2 = 66.4%)。结果证明,血脂异常与 COVID-19 的严重程度和死亡率增加有关。因此,我们应监测血脂并积极治疗 COVID-19 血脂异常患者,以降低严重程度和死亡率。由 26 项队列研究和 2 项病例对照研究组成。血脂异常与 COVID-19 的严重程度相关(优势比 [OR] = 1.27,95% 置信区间 [CI] 1.11–1.44,P = 0.038,I2 = 39.8%)。此外,与没有血脂异常的患者相比,血脂异常患者的死亡风险增加了 2.13 倍(95% CI 1.84–2.47,P = 0.001,I2 = 66.4%)。结果证明,血脂异常与 COVID-19 的严重程度和死亡率增加有关。因此,我们应监测血脂并积极治疗 COVID-19 血脂异常患者,以降低严重程度和死亡率。与没有血脂异常的患者相比,死亡风险增加 13 倍(95% CI 1.84–2.47,P = 0.001,I2 = 66.4%)。结果证明,血脂异常与 COVID-19 的严重程度和死亡率增加有关。因此,我们应监测血脂并积极治疗 COVID-19 血脂异常患者,以降低严重程度和死亡率。与没有血脂异常的患者相比,死亡风险增加 13 倍(95% CI 1.84–2.47,P = 0.001,I2 = 66.4%)。结果证明,血脂异常与 COVID-19 的严重程度和死亡率增加有关。因此,我们应监测血脂并积极治疗 COVID-19 血脂异常患者,以降低严重程度和死亡率。
更新日期:2021-07-27
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