Despite the increasing incidence of anaphylaxis, its underlying molecular mechanisms and biomarkers for appropriate diagnosis remain undetermined. The rapid onset and potentially fatal outcome in the absence of managed treatment prevent its study. Up today, there are still no known biomarkers that allow an unequivocal diagnosis. Therefore, the aim of this study was to explore metabolic changes in patients suffering anaphylactic reactions depending on the trigger (food and/or drug) and severity (moderate and severe) in a real-life set-up.

中文翻译：

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过敏反应的表征揭示了取决于严重程度和触发因素的不同代谢变化

尽管过敏反应的发生率不断增加，但其潜在的分子机制和用于适当诊断的生物标志物仍未确定。在缺乏管理治疗的情况下快速发作和潜在的致命结果阻止了其研究。直到今天，仍然没有已知的生物标志物可以明确诊断。因此，本研究的目的是在现实生活中探索过敏反应患者的代谢变化，具体取决于触发因素（食物和/或药物）和严重程度（中度和重度）。