Macroscopic thromboembolic disease has been associated with canine neoplasia, whereas prevalence studies of concurrent microthrombi and tumour-cell emboli are lacking. This retrospective study investigated microthrombi and tumour cell emboli by reviewing pathology records of dogs diagnosed with lymphoma, sarcoma, carcinoma and mast cell tumours with a concurrent description of thrombi or emboli. Pathology reports and medical records of cases with either tumour biopsies and/or post mortems with a diagnosis of neoplasia were reviewed for the presence of microthrombi, macrothrombi and/or tumour-cell emboli and the association with tumour type. Of the 28 895 canine cases in the database, 21 252 (73.5%) were antemortem biopsy specimens and 7643 were post mortems (26.5%); 2274 solid tumours were identified, 2107 (92.7%) were antemortem biopsy diagnoses and 167 (7.3%) were post mortem diagnoses. The prevalence of solid tumour types in the database (28 895 cases) was 872 (3.0%) lymphoma, 722 (2.5%) sarcoma, 455 (1.6%) carcinoma and 225 (0.8%) mast cell tumour. The prevalence of microthrombi associated with these tumours was 58/2274 (2.6%). Intra-tumoral microthrombi were reported in 53/2274 (2.3%) cases, the majority in sarcomas (37/53, 69.8%). No macrothrombi were reported. Tumour-cell emboli were identified in 39/2274 (1.7%) cases, 31/39 (79.5%) were extra-tumoral or distant emboli, and carcinoma the most commonly associated tumour (29/39; 74.4%). Microthrombi were reported in 2.6% of cases, the majority in sarcomas and tumour-cell emboli were identified in 1.7% of cases, the majority carcinomas. Prospective investigations are necessary to explore the potential clinical and prognostic implications of microthrombi and tumour-cell emboli in canine neoplasia.

中文翻译：

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肿瘤内和远处血栓的发生率，以及犬肿瘤中的肿瘤细胞栓子

肉眼可见的血栓栓塞性疾病与犬肿瘤形成有关，而同时发生的微血栓和肿瘤细胞栓子的流行率研究还很缺乏。这项回顾性研究通过回顾诊断为淋巴瘤、肉瘤、癌和肥大细胞肿瘤的狗的病理记录以及血栓或栓子的同时描述来调查微血栓和肿瘤细胞栓子。对肿瘤活检和/或诊断为肿瘤的尸检病例的病理报告和医疗记录进行了审查，以了解微血栓、大血栓和/或肿瘤细胞栓子的存在以及与肿瘤类型的关联。在数据库中的 28 895 例犬类病例中，21 252 例（73.5%）是死前活检标本，7643 例是死后活检标本（26.5%）；鉴定出 2274 个实体瘤，2107 个（92. 7%) 是死前活检诊断，167 (7.3%) 是死后诊断。数据库中实体瘤类型的患病率（28 895 例）为 872 例（3.0%）淋巴瘤、722 例（2.5%）肉瘤、455 例（1.6%）癌和 225 例（0.8%）肥大细胞瘤。与这些肿瘤相关的微血栓发生率为 58/2274 (2.6%)。在 53/2274 (2.3%) 例中报告了肿瘤内微血栓，其中大部分为肉瘤 (37/53, 69.8%)。没有报告大血栓。在 39/2274 (1.7%) 例中发现了肿瘤细胞栓子，其中 31/39 (79.5%) 是肿瘤外或远处栓子，而癌是最常见的相关肿瘤 (29/39; 74.4%)。在 2.6% 的病例中报告了微血栓，在 1.7% 的病例中发现了大多数肉瘤和肿瘤细胞栓子，大多数是癌。