Parkinson’s disease (PD), the second most common neurodegenerative disease, is clinically characterized by both motor and non-motor symptoms. Although overall great achievements have been made in elucidating the etiology and pathogenesis of PD, the exact mechanisms of this complicated systemic disease are still far from being clearly understood. Consequently, most of the currently-used diagnostic tools and therapeutic options for PD are symptomatic. In this perspective review, we highlight the hot topics in recent PD research for both clinicians and researchers. Some of these hot topics, such as sleep disorders and gut symptoms, have been neglected but are currently emphasized due to their close association with PD. Following these research directions in future PD research may help understand the nature of the disease and facilitate the discovery of new strategies for the diagnosis and therapy of PD.

帕金森氏病 (PD) 是第二种最常见的神经退行性疾病，临床上以运动和非运动症状为特征。尽管在阐明 PD 的病因学和发病机制方面取得了全面的巨大成就，但这种复杂的全身性疾病的确切机制仍远未被清楚地了解。因此，大多数目前使用的 PD 诊断工具和治疗选择都是有症状的。在这篇综述中，我们重点介绍了临床医生和研究人员近期 PD 研究中的热门话题。其中一些热门话题，如睡眠障碍和肠道症状，一直被忽视，但由于它们与 PD 密切相关，目前受到强调。