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Chemical Constituents of Date Palm (Phoenix dactylifera L.) Fruit-Free Bunches and Their Biological Activities
Pharmaceutical Chemistry Journal ( IF 0.8 ) Pub Date : 2021-07-27 , DOI: 10.1007/s11094-021-02432-x
Hoda M. Fathy 1 , Reham S. Ibrahim 1 , Amr El-Hawiet 1 , Abdallah A. Omar 1
Affiliation  

Phytochemical investigation of Phoenix dactylifera L. (date palm) fruit-free bunches lead to the isolation of seven compounds, including new trisaccharide (β-D-glucopyranosyl-(1→2)-β-D-fructofuranosyl-(6→6)-α- D-glucopyranoside), two flavonoid glycosides (isorhametin-3-O-β-D-glucoside and neodiosmin), three sugars (maltotriose, maltose and sucrose) and β-sitosterol-3-O-β-D-glucoside. The structures were elucidated using detailed analysis of one- and two-dimensional nuclear magnetic resonance spectra and mass spectrometric data along with comparison to published data. Computational and pharmacological investigations were performed. First, molecular docking studies were used to explore interaction of the new trisaccharide and its derivatives as well as the isolated flavonoid glycosides with human leukotriene A4 hydrolase (LTA4H) in the search for clinically active LTA4 H inhibitors. Second, study of the butanol fraction of the palm fruit-free bunch and the new trisaccharide showed their significant antimicrobial activity against Candida albicans and moderate activity against Bacillus subtilis. Finally, measuring the in-vitro prothrombin time (PT) and activated partial thromboplastin time (APTT) showed a promising anticoagulant activity of the total ethanolic extract, butanol fraction and the new trisaccharide.



中文翻译:

枣椰树(Phoenix dactylifera L.)无果束的化学成分及其生物活性

的植物化学研究海枣L.(枣椰树)无果串导致分离出七种化合物,包括新的三糖(β-D-吡喃葡萄糖基-(1→2)-β-D-呋喃果糖基-(6→6)-α-D-吡喃葡萄糖苷)、两种黄酮苷(isoorhametin-3-O-β-D-glucoside 和 neodiosmin)、三种糖(麦芽三糖、麦芽糖和蔗糖)和 β-sitosterol-3-O-β-D-glucoside。使用一维和二维核磁共振谱和质谱数据的详细分析以及与已发表数据的比较来阐明结构。进行了计算和药理学研究。首先,分子对接研究用于探索新的三糖及其衍生物以及分离的黄酮苷与人白三烯 A4 水解酶 (LTA 4H) 寻找具有临床活性的 LTA 4 H 抑制剂。其次,对棕榈无果束的丁醇部分和新三糖的研究表明它们对白色念珠菌具有显着的抗菌活性,对枯草芽孢杆菌具有中等活性。最后,测量体外凝血酶原时间 (PT) 和活化部分凝血活酶时间 (APTT) 表明总乙醇提取物、丁醇部分和新三糖具有良好的抗凝活性。

更新日期:2021-07-27
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