Myelin water fraction (MWF) is a histopathologically validated in vivo myelin marker. As MWF is the proportion of water with a short T₂ relative to the total water, increases in water from edema and inflammation may confound MWF determination in multiple sclerosis (MS) lesions. Total water content (TWC) measurement enables calculation of absolute myelin water content (MWC) and can be used to distinguish edema/inflammation from demyelination. We assessed what influence changes in total water might have on MWF by calculating MWC values in new MS lesions.

中文翻译：

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新发多发性硬化病灶的含水量变化对髓鞘水分值的测定影响很小

髓鞘水分数 (MWF) 是一种经过组织病理学验证的体内髓鞘标记物。由于 MWF 是具有短 T ₂的水相对于总水的比例，因此水肿和炎症引起的水的增加可能会混淆 MWF 在多发性硬化 (MS) 病变中的测定。总含水量 (TWC) 测量可以计算绝对髓磷脂含水量 (MWC)，并可用于区分水肿/炎症与脱髓鞘。我们通过计算新 MS 病变中的 MWC 值来评估总水的变化可能对 MWF 产生的影响。